New Type Scaffold Biomaterials with Magnesium Accelerating Osteoblast Adhesion and Bone Formation
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概要
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It was reported that the cationic ions are related to the adhesion behavior of integrin. Especially divalent cations such as Mg^<2+> ions play some role in cell adhesion. Thus, magnesium seems to be an important factor in controlling bone metabolism. Recently, scaffold biomaterials have been focused in the tissue engineering field. FGMgCO_3Ap-collagen composite was made by mixing the functionally graded CO_3apatite containing Mg with collagen. Modification of gradational Mg^<2+> ions on the apatite crystals promoted cell adhesion. Furthermore, as a scaffold material, the FGMgCO_3Ap-collagen composite suggested contributing to bone formation. Mg^<2+> ions may contribute to the bone metabolism of osteoclast and osteoblast action with the integrins at their cell surfaces.
- 2004-03-30
著者
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OKAZAKI Masayuki
Department of Biomaterials Science, Graduate School of Biomedical Science, Hiroshima University
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Okazaki Masayuki
Department Of Biomaterials Science Hiroshima University Faculty Of Dentistry
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Okazaki Masayuki
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
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