Osteopontin-derived Peptide SVVYGLR Induces Angiogenesis In Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Our previous study reported that an osteopontin-derived peptide SVVYGLR activates the adhesion, migration and tube formation abilities of endothelial cells in vitro. The present study investigated angiogenesis due to synthetic SVVYGLR and mutant peptides in vivo. Mutant peptides (n = 7) were synthesized by substituting alanine (A) for one of the 7 amino acids comprising SVVYGLR. In dorsal air sac assay, mouse dorsal skin 5 days after implantation of a chamber filled with SVVYGLR had approximately the same number of newly formed blood vessels to that filled with vascular endothelial growth factor (VEGF). The ability of angiogenesis due to SVVAGLR was significantly lower than that due to other 6 mutant peptides and SVVYGLR. This indicates that tyrosine (Y) plays an important role in angiogenesis due to SVVYGLR.
- 日本歯科理工学会の論文
著者
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OKAZAKI Masayuki
Department of Biomaterials Science, Graduate School of Biomedical Science, Hiroshima University
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MATSUMOTO TAKUYA
Department of Earth and Space Science, Graduate School of Science, Osaka University
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TAKAHASHI Junzo
Department of Dental Materials Science and Technology, Faculty of Dentistry, Osaka University
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Matsumoto Takuya
Division Of Oromaxillofacial Regeneration Course For Integrated Oral Sciences And Stomatology Osaka
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Matsumoto Takuya
Department Of Chemical Science And Engineering Graduate School Of Engineering Kobe University
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HAMADA Yoshinosuke
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
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DAITO Michiharu
Department of Pediatric Dentistry, Osaka Dental University
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MATSUURA Nariaki
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
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YUKI Kanako
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
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FUJITANI Wataru
Department of Materials Science and Engineering, Osaka University Graduate School of Engineering
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KOBASHI HASHIDA
Department of Biomaterials Science, Osaka University Graduate School of Dentistry
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HARUTSUGU Kentaro
Department of Pediatric Dentistry, Osaka Dental University
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NOKIHARA Kiyoshi
Hipep Laboratories Inc.
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Yuki Kanako
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
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Kobashi Hashida
Department Of Biomaterials Science Osaka University Graduate School Of Dentistry
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Kobashi Hashida
Department Of Biomaterial Science Graduate School Of Dentistry Osaka University
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Daito M
Osaka Dental Univ. Osaka Jpn
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Daito Michiharu
Department Of Pediatric Dentistry Osaka Dental University
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Takahashi Junzo
Ids Co. Ltd Osaka Jpn
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Okazaki Masayuki
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
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Okazaki Masayuki
Department Of Biomaterials Science Graduate School Of Biomedical Science Hiroshima University
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Matsuura Nariaki
Department Of Molecular Pathology Course Of Allied Health Sciences Graduate School Of Medicine Osaka
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Harutsugu Kentaro
Department Of Pediatric Dentistry Osaka Dental University
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Hamada Yoshinosuke
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science:de
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Date Masataka
Department Of Pharmacology Osaka Dental University
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Takahashi J
Division Of Oral Maxillofacial Regeneration Graduate School Of Dentistry Osaka University
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Takahashi Junzo
The Research Institute For Iron Steel And Other Metals Tohoku University
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Takahashi Junzo
Department Of Dental Materials Science And Technology Faculty Of Dentistry Osaka University
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Okazaki Masayuki
Hiroshima Univ. Hiroshima Jpn
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Okazaki Masayuki
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
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Fujitani W
Division Of Materials And Manufacturing Science Graduate School Of Engineering Osaka University
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Fujitani Wataru
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
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Matsumoto Takuya
Department Of Chemical Engineering And Materials Science Doshisha University
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Matsuura Nariaki
Department Of Functional Diagnostic Science Osaka University Graduate School Of Medicine
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Daito Miho
Department Of Pediatric Dentistry Osaka Dental University
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Matsuura Nariaki
Department Of Cardiothoracic Surgery The University Of Tokyo
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Nokihara K
Hipep Laboratories
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Nokihara Kiyoshi
Hipep Laboratories
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Matsumoto Takuya
Department Of Bioregulatory Medicine Ehime University Graduate School Of Medicine
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Matsumoto Takuya
Department Of Biomaterials Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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MATSUMOTO Takuya
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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HAMADA Yoshinosuke
Department of Functional Diagnostic Science,
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