Control of Pore Size in L-lactide/ε-caprolactone Copolymer Foams for Tissue Regeneration by the Freeze-drying Method
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概要
- 論文の詳細を見る
In the regeneration and repair of missing tissues, synthetic polymer scaffolds need many pores to involve cells and to supply cells with nutrients. The control of the pore size of biodegradable L-lactide/ε-caprolactone copolymer foams was studied by changing the polymer concentration and the cooling temperature in the freeze-drying method. The mixtures of polymer and 1, 4-dioxane solution were poured into an 18-8 stainless steel Petri dish and frozen. The pore size of a polymer foam tends to increase from the bottom towards the top of a Petri dish. The pore size decreased to one-half with increasing polymer concentration (1 to 10 wt%). The mean pore size in foams of 8% polymer concentration decreased from 100 μm to 20 μm as cooling temperature was lowered. This suggests that the higher cooling rate due to lower cooling temperature can produce smaller ice-crystals and result in smaller pores.
- 日本歯科理工学会の論文
著者
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TAKAHASHI Junzo
Division of Oromaxillofacial Regeneration, Course for Integrated Oral Sciences and Stomatology, Osak
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NAKAO Hiroyuki
Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak
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Matsumoto Takuya
Division Of Oromaxillofacial Regeneration Course For Integrated Oral Sciences And Stomatology Osaka
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Matsumoto T
Division Of Biomaterials Science Graduate School Of Dentistry Osaka University
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HYON Suong-Hyu
Department of Medical Simulation Engineering, Institute for Frontier Medical Science, Kyoto Universi
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TSUTSUMI Sadami
Department of Medical Simulation Engineering, Institute for Frontier Medical Science, Kyoto Universi
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Nakao Hiroyuki
Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki
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Hyon S‐h
Department Of Medical Simulation Engineering Institute For Frontier Medical Science Kyoto University
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Takahashi Junzo
Division Of Biomaterial Science Graduate School Of Dentistry Osaka University
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Takahashi Junzo
Division Of Biomaterials Science Graduate School Of Dentistry Osaka University
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Tsutsumi Sadami
Department Of Medical Simulation Engineering Institute For Frontier Medical Science Kyoto University
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Nakao Hiroyuki
Division Of Biomaterials Science Graduate School Of Dentistry Osaka University
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MATSUMOTO Takuya
Division of Cardiology, Sanda City Hospital
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