Fabrication of Porous Particulate for the Scaffold by Applying Solution Spraying Method
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概要
- 論文の詳細を見る
A simple and novel method-in the form of solution spraying-was developed to fabricate biodegradable, porous poly (L-lactic acid) (PLLA) particulates for scaffold. PLLA pellets were dissolved in an organic solvent. Then, 5% PLLA-dioxane solution was sprayed using an air-assisted atomizer with a nozzle diameter of 2.5 mm at an air flow rate of 15 L/min. After the sprayed solution solidified in liquid nitrogen, spherical particulates with median diameter of 225 μm were obtained. Morphology of sprayed products could be altered by varying the fabrication conditions. When nozzle diameter was reduced to 1.5 mm, sprayed products became fibrous. When the concentration of PLLA-dioxane solution was increased, the diameter of particulates increased too. On the other hand, when air flow rate was increased, the diameter of particulates decreased. Likewise, solidification conditions also affected the morphology of sprayed products, such that they were either thin film-like or in particulate form. Based on the results of the present study, we concluded that PLLA particulates of varying morphologies could be obtained by adjusting the fabrication conditions.
- 日本歯科理工学会の論文
著者
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SOHMURA Taiji
Division of Oralmaxillofacial Regeneration, Osaka University Graduate School of Dentistry
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TAKAHASHI Junzo
Division of Oromaxillofacial Regeneration, Course for Integrated Oral Sciences and Stomatology, Osak
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Sohmura Taiji
Division Of Biomaterial Science Graduate School Of Dentistry Osaka University
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Yamamoto Takehiro
Department of Mechanical Engineering, Osaka University
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Niwa Hitoshi
Division Of Dental Anesthesiology Graduate School Of Dentistry Osaka University
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TERAOKA Fumio
Division of Biomaterial Science, Graduate School of Dentistry, Osaka University
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Takahashi Junzo
Division Of Biomaterial Science Graduate School Of Dentistry Osaka University
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TAMASAKI Hideki
Division of Dental Anesthesiology, Graduate School of Dentistry, Osaka University
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HIROSE Yousuke
Department of Mechanophysics Engineering, Osaka University
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Hirose Yousuke
Department Of Mechanophysics Engineering Osaka University
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Tamasaki Hideki
Division Of Dental Anesthesiology Graduate School Of Dentistry Osaka University
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Yamamoto Takehiro
Department Of Mechanical Engineering Graduate School Of Engineering Osaka University
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Yamamoto Takehiro
Department Of Mechanophysics Engineering Osaka University
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Yamamoto Takehiro
Department Of Chemistry Okayama University Of Science
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Teraoka Fumio
Division Of Biomaterial Science Graduate School Of Dentistry Osaka University
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