Stem cells in dentistry – Part II: Clinical applications
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概要
- 論文の詳細を見る
New technologies that facilitate solid alveolar ridge augmentation are receiving considerable attention in the field of prosthodontics because of the growing requirement for esthetic and functional reconstruction by dental implant treatments. Recently, several studies have demonstrated potential advantages for stem-cell-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now an excellent candidate for tissue replacement therapies, and tissue engineering approaches and chair-side cellular grafting approaches using autologous MSCs represent the clinical state of the art for stem-cell-based alveolar bone regeneration. Basic studies have revealed that crosstalk between implanted donor cells and recipient immune cells plays a key role in determining clinical success that may involve the recently observed immunomodulatory properties of MSCs. Part II of this review first overviews progress in regenerative dentistry to consider the implications of the stem cell technology in dentistry and then highlights cutting-edge stem-cell-based alveolar bone regenerative therapies. Factors that affect stem-cell-based bone regeneration as related to the local immune response are then discussed. Additionally, pre-clinical stem cell studies for the regeneration of teeth and other oral organs as well as possible applications of MSC-based immunotherapy in dentistry are outlined. Finally, the marketing of stem cell technology in dental stem cell banks with a view toward future regenerative therapies is introduced.
- 社団法人 日本補綴歯科学会の論文
著者
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Egusa Hiroshi
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
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Nishimura Masahiro
Department Of Prosthetic Dentistry Division Of Cervico-gnathostomatology Programs For Applied Biomed
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Akiyama Kentaro
Department Of Pharmacology Yamanashi Medical College
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Atsuta Ikiru
Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
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Sonoyama Wataru
Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School Medicine, Dentistry and Pharmaceutical Sciences
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Sonoyama Wataru
Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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