Analysis of T Cell Subsets in Patients with Malignant Brain, Tumors
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概要
- 論文の詳細を見る
Lymphocyte subpopulations were monitored by means of monoclonal antibodies in 89 patients with primary or metastatic malignant brain tumors. In 27 normal volunteers, the ratio of helper/inducer (Leu 3a) to suppressor/cytotoxic (Leu 2a) T cells was 1.84±0.32 (mean±SD). The ratio decreased to 1.21±0.34 in 32 patients who were newly diagnosed as malignant gliomas, and to 1.01±0.34 in 21 patients with metastatic brain tumors. Among patients with malignant gliomas whose Karnofsky performance status was over 40%, the ratio increased during remission and/or when computed tomography showed tumor reduction. These results suggest that the suppressor T cells are more prevalent than helper T cells in patients with malignant brain tumors. Furthermore, immunosuppression and tumor load appear to be related, since the Leu 3a:Leu 2a ratio increased following effective treatment and tumor reduction in patients with Karnofsky ratings of over 40% but decreased in patients who were in the terminal stage of their disease.
- 日本脳神経外科学会の論文
- 1988-10-15
著者
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Ono Koji
Department Of Cardiology Gifu Prefectural General Medical Center
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Ono Koji
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Tanaka Ryuichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Takai Nobuyuki
Department Of Neurological Surgery Niigata Rosai Hospital
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Takai Nobuyuki
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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Tanaka Ryuichi
Department Of Liberal Arts Faculty Of Science And Technology Tokyo University Of Science
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