Expression of MHC Class II Antigens on Human Glioma Cells Modulated by Transfection with Genes Encoding These Antigens
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概要
- 論文の詳細を見る
Four glioma cell lines not expressing human leukocyte antigen (HLA)-DR or DQ did so after transfection with genes encoding HLA-DR and DQ. The glioma cells had enhanced ability to stimulate allogeneic and autologous responding lymphocytes in the mixed lymphocyte response (MLR). Glioma cells expressing only HLA-DR had weaker MLR enhancement than those expressing both HLA-DR and DQ or only HLA-DQ. Stimulation by transformed glioma cells increased the killing activity of responding lymphocytes against autologous glioma cells 2.0 times. Both HLA-DR and DQ are important in MLR, and the immunogenicity of glioma cells might be increased by transfection with genes encoding these antigens.
- 日本脳神経外科学会の論文
- 1991-10-15
著者
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Tanaka Ryuichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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Yoshida Seiichi
Department Of Neurosurgery Brain Research Institute School Of Medicine Niigata University
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Takahashi Hiroaki
Department Of Biochemistry And Molecular Biology Graduate School Of Science And Engineering Saitama
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Takahashi Hiroaki
Department Of Obstetrics And Gynecology School Of Medicine Niigata University
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Tanaka Ryuichi
Department Of Liberal Arts Faculty Of Science And Technology Tokyo University Of Science
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Tanaka Ryuichi
Department Of Neurosurgery Brain Research Institute School Of Medicine Niigata University
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