Precancerous Lesions in the Large Intestine of Rodents
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概要
- 論文の詳細を見る
As precancerous lesions for large bowel cancers, early appearing lesions like aberrant crypt foci (ACF) are recognized. Recently, we identified β-cetenin accumulated crypts (BCAC) in the colonic mucosa of rats given a colon carcinogen. BCAC have frequent β-catenin gene mutations and their pathological features are different from those of ACF. Further comparative studies on the molecular pathology and biology of both lesions, gave rise to evidences that BCAC are probably the direct precursor for the large intestinal cancers in rodents. The newly identified lesions are suggested to be a reliable biomarker for the risk assessment of environmental chemicals and for the screening of cancer preventing agents.
- 日本毒性病理学会の論文
- 2002-06-30
著者
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Mori Hideki
Department Of Pathology Gifu University School Of Medicine
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Mori Hideki
Department Of Anatomy Okayama University Medical School
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Yamada Yasuhiro
Department Of Pathology Gifu University School Of Medicine
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Yamada Yasuhiro
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo
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