Histamine-Releasing Properties of T-3762,a Novel Fluoroquinolone Antimicrobial Agent in Intravenous Use. I. Effects of Doses and infusion Rate on Blood Pressure, Heart Rate and Plasma Histamine Concentration
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概要
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T-3762,a newly developed fluoroquinolone antimicrobial agent, ciprofloxacin (CPFX) and ofloxacin (OFLX) were administered intravenously to anesthetized dogs in intravenous infusion, and blood pressure, heart rate and plasma histamine concentrations were monitored. T-3762 decreased blood pressure by 12.0%, without alterations in heart rate and plasma histamine concentration, only when infused at 150 mg/min. CPFX and OFLX both produced a rapid decrease in blood pressure in a dose-related manner, with an accompanying decrease in heart rate, but to a lesser extent. After infusion at 150 mg/min, CPFX caused death in 2 animals within a few minutes, while OFLX produced maximum decreases in blood pressure and heart rate, by 69.0% abd 26.4%, respectively. The infusion of these 2 agents resulted in dose-related increases in plasma histamine concentrations parallel to the decreases in blood pressure : the miximum, attained with CPFX at 50 mg/min and OFLX at 150 mg/min, were 379.2 and 167.8 ng/ml, respectively. For CPFX and OFLX, the relationship between the maximum levels of decreased blood pressure and increased histamine concentration in plasma was highly significant. The hypotension induced by CPFX was efficiently reduced by the pretreatment of animals with antihistamines. The results from this study suggest that hypotension induced in dogs following the intravenous infusion of fluoroquinolone antimicrobial agents may be dependent on their ability to cause histamine release from cells and tissues, and indicates that T-3762 is devoid of this ability in comparison to CPFX and OFLX.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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古畑 公夫
北里大薬
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Narita H
Toyama Chemical Co. Ltd. Toyama Jpn
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NARITA Hirokazu
Research Institute for Environmental Management Technology National Institute of Advanced Industrial
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WATANABE Yasuo
Research Laboratories, Toyama Chemical Co., Ltd.
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HAYAKAWA Hiroyoshi
Research Laboratories, Toyama Chemical Co. Ltd
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Watanabe Yoshiko
Department Of Pharmacology Kobe Pharmaceutical University
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Narita H
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd
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FURUHATA Kunikazu
Research Laboratories, Toyama Chemical Co., Ltd.
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SOUMI Keiji
Research Laboratories, Toyama Chemical Co., Ltd.,
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ARAI Hirotoshi
Research Laboratories, Toyama Chemical Co., Ltd.,
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Furuhata K
Research Laboratories Toyama Chemical Co. Ltd.
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Watanabe Yasuo
Research Laboratories Of Toyama Chemical Co Ltd
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Soumi Keiji
Clinical Research Department Toyama Chemical Co. Ltd.
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Hayakawa H
Research Laboratories Toyama Chemical Co. Ltd.
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Hayakawa Hiroyoshi
Research Laboratories Toyama Chemical Co. Ltd
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Arai Hirotoshi
Research Laboratories, Toyama Chemical Co., Ltd.
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WATANABE Yasuo
Research and Development Division, Oriental Yeast Co., Ltd.
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