難治性疾患をターゲットとしたペプチド創薬
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概要
著者
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堤 浩
東医歯大生材工研
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藤井 信孝
京都大学大学院薬学研究科 医薬創成情報科学専攻
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藤井 信孝
京都大学薬学研究科
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Tamamura Hirokazu
Graduate School Of Pharmaceutical Sciences Kyoto University
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玉村 啓和
京都大学大学院薬学研究科
関連論文
- O-80 膵癌の浸潤転移におけるStromal Derived Factor-1 (SDF-1)の関与について
- Solution-Phase Synthesis of an Anti-human Immunodeficiency Virus Peptide, T22 ([Tyr^, Lys^7]-Polyphemusin II), and the Modification of Trp by the p-Methoxybenzyl Group of Cys during Trimethylsilyl Trifluoromethanesulfonate Deprotection
- Molecular Parameters for the Anti-Human Immunodeficiency Virus Activity of T22 ([Tyr^, Lys^7]-Polyphemusin II)
- HIV感染のコレセプター,CXCR4,を標的とした抗HIV薬の開発
- 2P055 ドッキングシミュレーションによるHIV-1インテグラーゼ阻害活性を有するペプチドの分子設計(蛋白質(構造・構造機能相関),ポスター発表,第45回日本生物物理学会年会)
- 膵癌におけるKiSS-1およびその受容体の発現と遊走能への関与
- 1P005抗HIVペプチドN36耐性株から誘導されたC34KQとN36の複合体のX線結晶解析
- SARS治療薬の展望 (特集 ウイルス感染症--基礎と臨床) -- (基礎)
- Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-human Immunodeficiency Virus Activity
- 猫乳腺腫瘍の転移におけるケモカインとケモカイン受容体の役割の検討(生化学)
- Synthesis of a CC Chemokine, vMIP-II, Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Its Biological Activity
- The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis
- New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
- A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
- CXCR4 Antagonists Identified as Anti-Cancer-Metastatic Agents
- Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study
- Development of Specific CXCR4 Inhibitors Based on an Anti-HIV Peptide, T140, and Their Structure-Activity Relationships Study
- Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1
- HIV-cell Fusion Inhibitors Targeted to the HIV Second Receptor : T22 and Its Downsized Analogs with High Activity
- ケミカルプロテオミクスによる創薬基盤の革新:情報から制御へ (特集 飛躍するケミカルバイオロジー--化学から生命現象を明らかに)
- Synthesis of Optically Pure 2-Aziridinemethanols : Versatile Synthetic Building Blocks
- Synthesis of CXCR4 Antagonists, T140 Derivatives with Improved Biostability, and Their SAR Study
- Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion
- Growth Factor
- 第5回メディシナルケミストリーシンポジウム
- 有機化学者のチャレンジ : 本物を目指して
- Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isostere and Its Biological Activity
- Design and Synthesis of Highly Active Anti-HIV Peptide Based on Gp41-C34 Peptide
- Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)
- Stereoselective Synthesis of Diketopiperazine Mimetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-S_N2' Reaction
- Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and their Application to a Cyclic RGD Peptide
- Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acid
- 難治性疾患をターゲットとしたペプチド創薬
- Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs
- Acceleration of the N^α-Deprotection Rate by the Addition of m-Cresol to Diluted Methanesulfonic Acid and Its Application to the Z(OMe)-Based Solid-Phase Syntheses of Human Pancreastatin-29 and Magainin 1
- Coreceptorを標的とした抗エイズ薬剤の開発状況
- HIV侵入の第二受容体に対する特異的拮抗剤の発見と応用に関する研究
- A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide
- アルケン型ジペプチドイソスターの合成法の開発と生理活性ペプチドの構造活性相関研究への応用
- ペプチドをリードとした創薬 (ケミカルバイオロジー) -- (生理活性物質のケミカルバイオロジー 創薬基盤としてのケミカルバイオロジー)
- プロテオミクスを基盤とするケミカルバイオロジー--情報から制御へ (特集 ケミカルバイオロジー--タンパク質機能を調節する小分子の世界)
- Enzyme Immunoassay of Thyrotropin Releasing Hormone (TRH)
- 膜融合阻害性抗ウイルスペプチドの開発 (特集/期待される生体機能分子の実用化)
- Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide
- Investigation of the Dimethylsulfoxide-Trifluoroacetic Acid Oxidation System for the Synthesis of Cystine-Containing Peptides
- Synthetic Study on Selenocystine-Contaning Peptides
- シスチン含有ペプチドの新規合成法
- 創薬科学賞受賞 レチノイドの医薬科学研究とタミバロテンの創製(紹介)
- 藤野政彦先生 紫綬褒章受賞
- Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
- 4-(Dimethylamino)phenacyl Group : New Photoremovable Protecting Group for Amines and Carboxylic Acids
- Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α, β-enoates and Their Application
- "あるもの"を探究する科学と"あるべきもの"を探究する科学
- 奨励賞受賞 山田健一氏の業績
- 薬学会賞受賞 伊藤信行氏の業績
- 奨励賞受賞 玉村啓和氏の業績
- 奨励賞受賞 大高 章氏の業績
- Stereoselective Synthesis of CF_2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptides
- Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies
- Efficient Induction of Pptide - Specific Cytotoxic T Lymphocytes by LPS - Activated Spleen Cells
- Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
- シスチン含有ペプチドの新規合成法
- Synthesis of (E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents
- Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Dipeptide Isosteres Utilizing Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions
- Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere
- 見えてきた! AIMECS 11
- Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI_2 Reagents