Electrical Detection of Silicon Binding Protein-Protein A Using a p-MOSFET Sensor

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概要

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• We have focused on silica binding protein (SBP)-tagged protein A as a key element for bio-sensing since this combined protein can act as an anchor for variety of target bio-molecules on Si and SiO_2 surfaces In this work, we confirmed the change in the surface potential with an attachment of SBP-tagged protein A on Si and SiO_2, and clearly observed an increase in conductivity of undoped poly-Si thin film on thermally -grown SiO_2 just after the attachment of silica binding protein-protein A on the surface. These results can be attributable to the change in the surface band bending of the poly-Si film. In p-channel FETs with a SiO_2/Si_3N_4 gate dielectric, the drain current was significantly decreased by the attachment of the SBP-tagged protein A. Observed decrease in the drain current can be interpreted in terms of screening of pre-existing negative charges at the interface between SiO_2 and Si_3N_4 and in the Si_3N_4 film with the attachment of electrically-polarized SBP-protein A.

• 2009-06-17

著者

• Miyazaki Seiichi

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Miyazaki S

  Hiroshima Univ. Higashi‐hiroshima Jpn

• Miyazaki Seiichi

  Dept. Of Electrical Engineering Hiroshima University

• Miyazaki Seiichi

  Faculty Of Engineering Hiroshima University

• MIYAZAKI S.

  Graduate School of Advanced Sciences of Matter, Hiroshima Univ.

• Murakami H.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Higashi S.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Miyazaki S

  Department Of Electrical Engineering Hiroshima University

• Murakami H

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Miyazaki S

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Mahboob S.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Katayama K.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Makihara K.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Ikeda M.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Hata H.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Kuroda A.

  Graduate School of Advanced Sciences of Matter, Hiroshima University

• Mahboob S.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Makihara K.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Higashi S.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Kohno A.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Katayama K.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Ikeda M.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

• Hata H.

  Graduate School Of Advanced Sciences Of Matter Hiroshima University

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