Microbial Production of 6-Hydroxynicotinic Acid, an Important Building Block for the Synthesis of Modern Insecticides
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概要
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Production of 6-hydroxynicotinic acid, an important starting material for the synthesis of modern pesticides through bacterial position-specific hydroxylation of nicotinic acid, was investigated. Resting cells of Serratia marcescens IFO 12648 were found to catalyze the potential hydroxylation activity of nicotinic acid to produce 6-hydroxynicotinic acid. THe optimum culture conditions of S. marcescens IFO 12648 for the accumulation of 60hydroxynicotinic acid were investigated. The addition to the culture medium of molybdenum and iron ions and of nicotinic acid as an inducer greatly enhanced the hydroxylation activity. Under the optimum conditions, 98.5% of the added 2.2M nicotinic acid was converted to 6-hydroxynicotinic acid, and the highest yield achieved was 301 g of 6-hydroxynicotinic acid per liter of reaction mixture containing 3.98 g dry weight of resting cells during a 72-h reaction at 35℃.
- 公益社団法人日本生物工学会の論文
- 1994-04-25
著者
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Yamane Tsuneo
Laboraotory Of Bioreaction Engineering Department Of Food Science And Technology Faculty Of Agricult
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Yamane Tsuneo
Laboratory Of Bioreaction Engineering Department Of Food Science And Technology School Of Agricultur
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Yamane T
Laboratory Of Molecular Biotechnology Graduate School Of Biological & Agricultural Sciences Nago
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Nagasawa Toru
Department Of Agricultural Chemistry Kyoto University
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Yamane Tsuneo
Department Of Applied Biological Sciences Faculty Of Agriculture Nagoya University
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Yamane Tsuneo
Laboratory Of Molecular Biotechnology Graduate School Of Bio- And Agro-sciences Nagoya University
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HURH BYUNGSERK
Department of Food Science and Technology, Faculty of Agriculture, Nagoya University
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OHSHIMA MIKIKO
Department of Applied Biological Sciences, Nagoya University
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Hurh Byungserk
Department Of Food Science And Technology Nagoya University
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Ohshima Mikiko
Department Of Applied Biological Sciences Nagoya University
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