Microbial HydroxyIation of 3-Cyanopyridine to 3-Cyano-6-hydroxypyridine
スポンサーリンク
概要
- 論文の詳細を見る
Approximately 4600 microorganisms isolated from soil and 110 bacteria from stock cultures were screened for their ability to hydroxylate 3-cyanopyridine (3-CP). Many strains were found to be capable of hydroxylating 3-CP. One of the strains with the highest activity was selected and identified as Comamonas testosteroni (MCI 2848). The product was isolated and identified as 3-cyano-6-hydroxypyridine (6-CHP). We optimized culture and reaction conditions for the production of 6-CHP by resting cells of MCI 2848. The activity was induced by addition of nicotinic acid or pyridine-3-aldoxime to the culture medium. The optimal temperature and pH of the reaction were 28℃ and 7.0, respectively. When resting cells was incubated with 3% (w/v) 3-CP, 95% of the 3-CP was converted into 6-CHP within 47h.
- 社団法人日本農芸化学会の論文
- 1995-04-23
著者
-
Nagasawa Toru
Department of Biomolecular Science, Gifu University
-
Ueda M
Mitsubishi Chemical Co. Ltd.
-
Yasuda Mari
Mitsubishi Chemical Co. Ltd.
-
Ueda M
Life Science Research Institute Snow Brand Milk Products Co. Ltd.
-
Ueda M
Shimane Univ. Matsue Jpn
-
Ueda Makoto
Mitsubishi Kasei Corporation, Research Center
-
Nagasawa Toru
Department Of Agricultural Chemistry Kyoto University
-
Sashida R
Mitsubishi Chemical Corp. Yokohama Jpn
-
Sakamoto Takeshi
Mitsubishi Chemical Co., Ltd.
-
Sashida Reiko
Mitsubishi Chemical Co., Ltd.
-
Morimoto Yuuki
Mitsubishi Chemical Co., Ltd.
-
Morimoto Y
Mitsubishi Chemical Co. Ltd. Ibaraki Jpn
-
Ueda Makoto
Mitsubishi Chemical Co. Research And Development Division Yokohama Research Center
-
Sakamoto Takeshi
Mitsubishi Chemical Co. Ltd.
-
Nagasawa Toru
Department Of Biological Function & Genetic Resources Sciences Faculty Of Agriculture Okayama Un
関連論文
- Bioconversion of 1-adamantanol to 1,3-adamantanediol using Streptomyces sp. SA8 oxidation system(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Purification, Characterization and Gene Cloning of Thermostable Ο-Acetyl-L-Homoserine Sulfhydrylase Forming γ-Cyano-α-Aminobutyric Acid (ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Purification, Characterization and Gene Cloning of Thermostable ο-Acetyl-L-Serine Sulfhydrylase Forming β-Cyano-L-Alanine
- Occurrence of Amidases in the Industrial Microbe Rhodococcus rhodochrous J1
- Purification and Characterization of Vanillyl-Alcohol Oxidase from Byssochlamys fulva V107
- Isolation and Identification of an Iron-Oxidizing Bacterium Which Can Grow on Tetrathionate Medium and the Properties of a Tetrathionate-Decomposing Enzyme Isolated from the Bacterium
- Purification and Some Properties of a Tetrathionate Decomposing Enzyme from Thiobacillus thiooxidans
- Bioelectrochemically Accelerated Microbial Conversion of Nicotinic Acid to 6-Hydroxynicotinic Acid on Microorganism-immobilized Column Electrolytic Flow System
- Expression of Human Erythropoietin in Cultured Tobacco Cells
- Purification and Characterization of Maleate Hydratase from Arthrobacter sp. strain MCI2612
- Novel Reversible Indole-3-carboxylate Decarboxylase Catalyzing Nonoxidative Decarboxylation(Microbiology & Fermentation Technology)
- Synthesis of D-Cysteine from a Racemate of 3-Chloroalanine by Phenylhydrazine-treated Cells of Pseudomonas putida CR 1-1
- Random Point Mutation Analysis of the Signal Peptide Cleavage Area of Bacillus stearothermophilus α-Amylase(Microbiology & Fermentation Industry)
- Microbial HydroxyIation of 3-Cyanopyridine to 3-Cyano-6-hydroxypyridine
- Production of Cyclofructan from Inulin by Bacillus circulans MCI-2554
- Purification of Inulin Fructotransferase (DFA I-producing) from Arthrobacter sp.MCI2493 and Production of DFA I from Inulin by the Enzyme
- Purification and Characterization of a Di-D-fructofuranose 2',1;2,1'-dianhydride Producing Enzyme from Streptomyces sp. MCI-2524
- Isolation of Advantageous Mutants of Pseudomonas chlororaphis B23 for the Enzymatic Production of Acrylamide(Microbilolgy & Fermentation Industry)
- Optimum Culture Conditions for Production by Pseudomonas chlororaphis B23 of Nitrile Hydratase(Microbiology & Fermentaion Industry)
- Efficient Production of Bacillus stearothermophilus α-Amylase in Bacillus brevis by Altering Its Signal Peptide
- Ferulic Acid Production from Clove Oil by Pseudomonas fluorescens E118
- Conversion of Isoeugenol into Vanillic Acid by Pseudomonas putida I58 Cells Exhibiting High Isoeugenol-Degrading Activity
- Microbial Synthesis of Coniferyl Alcohol by the Fungus Byssochlamys fulva V107
- Production of Novel Branched Cyclofructans by Bacillus subtilis MCI-2834
- Enzymatic Functionalization of Aromatic N-Heterocycles : Hydroxylation and Carboxylation
- Purification and Characterization of Nicotinic Acid Dehydrogenase from Pseudomonas fluorescens TN5
- Microbial Production of 6-Hydroxynicotinic Acid, an Important Building Block for the Synthesis of Modern Insecticides
- Production of 6-Hydroxynicotinic Acid from Nicotinic Acid by Resting Cells of Pseudomonas fluorescens TN5
- Purification and Characterization of a Novel (R)-Imine Reductase from Streptomyces sp. GF3587
- Evaluation of Brittleness of Porcelain Fused to Pure Titanium by Fracture Toughness, Hardness and Fracture Energy
- Purification and Characterization of an ε-Poly-L-Lysine-Degrading Enzyme from the ε-Poly-L-Lysine-Tolerant Chryseobacterium sp. OJ7 (ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Purification and Characterization of a Novel (R)-Imine Reductase from Streptomyces sp. GF3587
- Oxidation of aromatic N-heterocyclic compounds to N-oxides by Verticillium sp. GF39 cells(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Enzymatic Synthesis of D-Cysteine by 3-Chloro-D-alanine Resistant Pseudomonas putida CR 1-1
- Syntheses of S-Substituted L-Homocysteine Derivatives by Cystathionine γ-Lyase of Streptomyces phaeochromogenes
- Structures of Rhodonocardins Produced by a Nocardia sp.