Syntheses of S-Substituted L-Homocysteine Derivatives by Cystathionine γ-Lyase of Streptomyces phaeochromogenes

概要

論文の詳細を見る
Cystathionine γ-lyase from Streptomyces phaeochromogenes catalyzes not only the α., γelimination reaction of L-cystathionine, but also the γ-replacement reaction of L-homoserine in the presence of thiol compounds. Substrates for the enzyme in the γ-replacement reaction were examined. It was found that D-cysteine, L- and D-homocysteine, and 3- and 2-mercaptopropionate served as preferable substrates in the γ-replacement reaction. D-Allocystathionine, *1 L- and meso-homolanthionine, S-carboxyethyl-L-homocysteine and S-methylcarboxymethyl-L-homocysteine were enzymatically synthesized from L-homoserine and the corresponding thiol compounds. The thus synthesized S-substituted L-homocysteine derivatives were isolated from large scale reaction mixtures and identified physicochemically.
社団法人日本農芸化学会の論文