A New Enzymatic Method for the Measurement of Creatinine Involving a Novel ATP-dependent Enzyme, N-Methylhydantoin Amidohydrolase

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概要

• 論文の詳細を見る

• A new enzymatic method for the measurement of serum and urine creatinine is described. The method is based on a novel microbial creatinine degradation pathway via N-methylhydantoin [Shimizu et al. , Clin. Chim. Acta, 185, 241-252 (1989)]. By using two novel enzymes, N-methylhydantoin amidohydrolase and N-carbamoylsarcosine amidohydrolase, as key enzymes, coupled with a colorimetric procedure for hydrogen peroxide detection, the creatinine level can be measured. The results obtained for human serum and urine show good correlation with those obtained by a standard chemical method based on the Jaffe reaction. The new method is simple and specific, and shows excellent sensitivity and reliability.

• 社団法人日本農芸化学会の論文
• 1995-12-23

著者

• Shimizu S

  Kyoto Univ. Kyoto Jpn

• SHIMIZU Sakayu

  Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University

• YAMADA Hideaki

  Department of Agricultural Chemistry, Kyoto University

• Yamada H

  Department Of Agricultural Chemistry Facutly Of Agriculture Kyoto University

• Ogawa Jun

  Department of Agricultural Chemistry, Kyoto University

• Nirdnoy Warawadee

  Department of Agricultural Chemistry, Kyoto University

• Tabata Masayoshi

  College of Medical Technology, Kyoto University

• Shimizu Sakayu

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

• Yamada H

  Department Of Biotechnology Faculty Of Engineering Tottori University

• Yamada H

  Res. Inst. Tuberculosis Tokyo Jpn

• Yamada Hideaki

  Biotechnology Research Center, Toyama Prefectural University

• Ogawa J

  Kyoto Univ. Kyoto Jpn

• Yamada H

  Department Of Agricultural Chemistry Kyoto University

• Tabata M

  Department Of Chemistry Faculty Of Science And Engineering Saga University

• Nirdnoy Warawadee

  Department Of Agricultural Chemistry Kyoto University

• Ogawa Jun

  Department Of Agricultural Chemistry Kyoto University

• Yamada Hideaki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

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