A New Method for 5-(4-Hydroxyphenyl)hydantoin Synthesis
スポンサーリンク
概要
- 論文の詳細を見る
5-(4-Hydroxyphenyl)hydantoin (p-HPH), an important intermediate in production of D-2-(4- hydroxyphenyl)glycine, was synthesized by employing new amidoalkylation reaction of phenol with glyoxylic acid and urea under acidic conditions, accompanied by formation of the isomer, i.e. 5-(2- hydroxyphenyl)hydantoin (o-HPH). The ratio of p-HPH was found to be mainly influenced by the reaction method (the manner of charging raw materials) and reaction conditions, particularly reaction temperature, although more p-HPH was always produced than o-HPH (p-HPH/o-HPH= 3-7). The reaction mechanism of HPH formation was also examined using possible the intermediates glyoxylurea, allantoin and p-hydroxymandelic acid.
- 社団法人 日本農芸化学会の論文
著者
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YAMADA Hideaki
Department of Agricultural Chemistry, Kyoto University
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TAKAHASHI SATOMI
Biochemical Research Laboratory, Kanegafuchi Chemical Industry Co., Ltd.,
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OHASHI Takehisa
Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd.
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Ohashi Takehisa
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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NAGAMACHI Tomoaki
Biochemical Research Laboratory, Kanegafuchi Chemical Industry Co., Ltd.
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YONEDA Kohji
Biochemical Research Laboratory, Kanegafuchi Chemical Industry Co., Ltd.
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Takahashi Satomi
Biochemical Research Laboratory Kanegafuchi Chemical Industry Co. Ltd.
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Yamada Hideaki
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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OHASHI Takehisa
Biochemical Research Laboratory, Kanegafuchi Chemical Industry Co., Ltd.
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TAKAHASHI Satomi
Biochemical Research Laboratory, Kanegafuchi Chemical Industry Co., Ltd.
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