Microbial Production of Theobromine from Caffeine

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概要

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• Production of theobromine from caffeine by caffeine-degrading bacteria was studied. We found that addition of metal ions such as Zn^<2+> to intact cells of a caffeine-degrading isolate from soil, Pseudomonas sp. No. 6, resulted in a high theobromine accumulation from caffeine. We hypothesized that Zn^<2+> acts as a selective inhibitor of one of the theobromine-demethylating enzymes and further screened for theobromine-producing activities in the presence of Zn^<2+> among a number of caffeine-using microorganisms. A strain identified taxonomically as Pseudomonas putida No. 352 showed the best productivity among 973 microorganisms of stock cultures and soil isolates. Culture conditions for the production of theobromine from caffeine by P. putida No. 352 were studied. Under optimal conditions, nearly 20 g/liter of theobromine was produced from caffeine in a yield of 92%.

• 社団法人日本農芸化学会の論文
• 1993-08-23

著者

• Asano Yasuhisa

  Biotechnology Research Center, Toyama Prefectural University

• Asano Y

  Department Of Immunology And Host Defenses Ehime University Graduate School Of Medicine

• YAMADA Hideaki

  Department of Agricultural Chemistry, Kyoto University

• Yamada H

  Department Of Agricultural Chemistry Facutly Of Agriculture Kyoto University

• Yamada H

  Department Of Biotechnology Faculty Of Engineering Tottori University

• Asano Y

  Toyama Prefectural Univ. Toyama Jpn

• Yamada H

  Res. Inst. Tuberculosis Tokyo Jpn

• Komeda Toshihiro

  Department of Agricultural Chemistry, Kyoto University

• Yamada Hideaki

  Biotechnology Research Center, Toyama Prefectural University

• Yamada H

  Department Of Agricultural Chemistry Kyoto University

• Asano Yasuhisa

  Biotechnology Res. Center And Dep. Of Biotechnology Toyama Prefectural Univ.

• Komeda T

  Central Laboratories For Key Technology Kirin Brewery Co. Ltd.

• Yamada Hideaki

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

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