Lipase-catalyzed Stereoselective Hydrolysis of 2-Acyloxy-3-chloropropyl p-toluenesulfonate
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概要
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Lipase-catalyzed Stereoselective hydrolysis of 2-acyloxy-3-chloropropyl p-toluenesulfonate (1) was investigated. From the screening tests, lipases from Pseudomonas aeruginosa, Aspergillus niger, Mucor species, Rhizopus delemar and Rhizopus japonicus were found to hydrolyze (R, S)-1 stereoselectively to afford (R)-1 and (S)-2-hydroxy-3-chloropropyl p-toluenesulfonate (2). Among these enzymes, the lipase from Pseudomonas aeruginosa was found to possess the highest hydrolytic activity and stereoselectivity in more than 99% e.e.
- 社団法人 日本農芸化学会の論文
著者
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Watanabe Kiyoshi
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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Ohashi Takehisa
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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Hamaguchi Shigeki
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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HAMAGUCHI Shigeki
Biochemical Research Laboratories, Kanegafuchi Chemical Industry, Co., Ltd.
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WATANABE Kiyoshi
Biochemical Research Laboratories, Kanegafuchi Chemical Industry, Co., Ltd.
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