Asymmetric Hydrolysis of (R, S)-5-Acetoxymethyl-3-terr-butyl-oxazolidin-2-one with Enzymes and Microorganisms
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概要
- 論文の詳細を見る
Enzymes and microorganisms were screened for the asymmetric hydrolysis of (R, S)-5-acetoxymethyl-3-tert-butyl-oxazolidin-2-one 1. Lipases from Pseudomonas aeruginosa and Alcaligenes species, and microorganisms which belong to Enterobacter species or Klebsiella species were found to hydrolyze 1 enantioselectively to give (R)-5-hydroxymethyl-3-tert-butyl-oxazolidin-2-one (R)-2 and (S)-1. (S)-2, one of the typical intermediates for preparing optically active β-blocking agents (β-blockers), was obtained with high enantiomeric excess (91- 98% e.e.) from (S)-1.
- 社団法人 日本農芸化学会の論文
著者
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KAWAHARADA Hajime
Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd.
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Hasegawa Junzo
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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Watanabe Kiyoshi
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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Kawaharada Hajime
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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Hamaguchi Shigeki
Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.
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