Nicardipine and Nifedipine Inhibit Fatty Acid Desaturases in Rat Liver Microsomes
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概要
- 論文の詳細を見る
Nicardipine and nifedipine, Ca channel blockers, inhibited rat liver microsomal desaturases, though verapamil, methoxyverapamil, cinnarizine, flunarizine, and diltiazem did not. However, nicardipine and nifedipine apparently did not inhibit the fungal desaturation in Mortierella alpina 1S-4. Nicardipine inhibited rat liver microsomal Δ5 desaturase specifically (50% inhibitory concentration, 170μM), and nifedipine inhibited Δ6 desaturase specifically (78μM). The inhibition by nicardipine and nifedipine is uncompetitive, the K_i values for Δ5 and Δ6 desaturases being 62 and 44μM, respectively.
- 社団法人日本農芸化学会の論文
- 1996-10-23
著者
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KAWASHIMA Hiroshi
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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AKIMOTO Kengo
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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JAREONKITMONGKOL Saeree
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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SHIRASAKA Norifumi
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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SHIMIZU Sakayu
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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Akimoto K
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:institute For Biomedica
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Jareonkitmongkol Saeree
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Shirasaka N
Kinki Univ. Nara Jpn
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Shirasaka Norifumi
Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University
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Shirasaka Norifumi
近畿大学 農学部
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Shirasaka Norifumi
Department Of Agricultural Chemistry Kyoto University
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Kawashima Hiroshi
Institute for Health Care Science, Suntory Ltd.
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Shimizu Sakayu
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Kawashima Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:institute For Biomedica
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Kawashima H
Institute For Health Care Science Research Center Suntory Ltd.
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Kawashima H
Suntory Ltd. Osaka Jpn
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Kawashima Hideaki
Graduate School Of Pharmaceutical Sciences Kyoto University
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