Cell Age Distribution of Erythrocytes at the Incidence of Cerebral Stroke in Stroke-Prone Spontaneously Hypertensive Rats, and Their Glutathione Peroxidase Activity
スポンサーリンク
概要
- 論文の詳細を見る
To study the mechanism of the fall of glutathione peroxidase(GSH-Px)activity in erythrocyte after cerebral strokes in stroke-prone spontaneously hypertensive rats (SHRSP), erythrocytes were fractionated into low density erythrocytes (LD-E)and high density erythrocytes (HD-E) by a density gradient centrifugal method using Percoll solution, and fluctuation of the distribution ratio and changes of GSH-Px activity in fractionated erythrocytes were investigated.The distribution ratio of LD-E and HD-E in erythrocytes of SHRSP was about 4:1 at 5 weeks of age (n=6), and the distribution to HD-E increased along with aging.While the distribution ratio was changed, however, there was no change in the GSH-Px activity in both LD-E and HD-E of erythrocytes.In senile, 30-week-old SHRSP (n=4) with advanced hypertension, the GSH-Px activity in the HD-E was lower, in proportion to the increase of the distribution rate against HD-E.On the other hand, in SHRSP (n=5) having cerebral stroke, the distribution ratio of LD-E and HD-E was about 1:4. The GSH-Px activity was 31, 4±2.9 units/10^<10> erythrocytes in LD-E, which was hardly different from the value of SHRSP without stroke (35.7±3.3 units/10^<10> erythrocytes).In HD-E, however, the activity was 18.2±2.2 units/10^<10> erythrocytes, being lower than the activity of SHRSP without stroke.At the moment when the GSH-Px activity had dropped to 17 units/mg hemoglobin, and the control diet was changed to one based on fish or a hydralazine treatment given, the activity recovered, and an increase in body weight and the distribution rate of the LD-E over HD-E was increased.It is clear from these experiments that the fall of erythrocyte GSH-Px activity observed after cerebral stroke is due to a decrease of LD-E and increase of HD-E, which has lowered activity. However, nothing definite is known on the relationship between the fall of GSH-Px activity in erythrocytes and disorder in cerebral tissue.It appears that the fall of the GSH-Px activity causes at least functional and structural changes in erythrocytes, which interfere with the dilivery of oxygen to peripheral tissues, triggering oxidation stress in cerebral tissues.
- 社団法人日本農芸化学会の論文
- 1998-03-23
著者
-
SHIRASAKA Norifumi
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
-
YOSHIZUMI Hajime
Department of Food and Nutrition, Faculty of Agriculture, Kinki University
-
MURAKAMI Tetsuo
Department of Food and Nutrition, Faculty of Agriculture, Kinki University
-
Shirasaka N
Kinki Univ. Nara Jpn
-
Shirasaka Norifumi
Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University
-
Shirasaka Norifumi
近畿大学 農学部
-
Shirasaka Norifumi
Department Of Agricultural Chemistry Kyoto University
-
Ito Hiroyuki
Division of cardiology, Saitama Medical Center
-
TAKEMORI Kumiko
Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University
-
Ito Hiroyuki
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
-
Yoshizumi Hajime
Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University
-
Yoshizumi Hajime
Institute For Fundamental Research Research Center
-
Yoshizumi Hajime
Kinki University
-
Yoshizumi Hajime
Department Of Food And Nutrition Faculty Of Agriculture Kin-ki University
-
Matsuo Takuya
First Department Of Anatomy Kinki University School Of Medicine
-
Matsuo Takuya
Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University
-
Takemori Kumiko
Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University
-
Ito Hiroyuki
Division Of Pathology Research Institute Of Hypertension Kinki University
-
TAKEMORI Kumiko
Department of Food and Nutrition, Kinki University Faculty of Agriculture
-
MURAKAMI Tetsuo
Department of Food and Nutrition Faculty of Agriculture Kinki University
関連論文
- Clinical Outcomes after Stenting with or without IVUS Guidance(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-125 Relation of ACE Inhibitor and β Blocker with Left Ventricular Remodeling in Patients after Coronary Artery Bypass Graft Surgery(Cardiovascular Surgery/CABG 1 (IHD) : OJ15)(Oral Presentation (Japanese))
- Nicardipine and Nifedipine Inhibit Fatty Acid Desaturases in Rat Liver Microsomes
- Inhibition of Rat Liver Microsomal Desaturases by Curcumin and Related Compounds
- The characteristics of desaturation of Trichoderma sp. AM076 and formation of 9,12,15-hexadecatrienoic acid (16:3ω1) through Δ15 desaturation of 9,12-hexadecadienoic acid
- Microbial Synthesis of trans Isomer of Eicosapentaenoic Acid (EPA) from the Chemically Synthesized Trans Isomer of Linolenic Acid by a Δ12 Desaturase-defective Mutant of Mortierella alpina 1S-4(Microbiology & Fermentation Technology)
- Inhibitory Effects of Capsaicinoids on Fatty Acid Desaturation in a Rat Liver Cell Line(Food & Nutrition Science)
- C19 Odd-chain Polyunsaturated Fatty Acids (PUFAs) Are Metabolized to C21-PUFAs in a Rat Liver Cell Line, and Curcumin, Gallic Acid, and Their Related Compounds Inhibit Their Desaturation
- Formation of 8, 11, 14-Octadecatrienoic Acid (18:3 n-4) from Naturally Occurring Unique Fatty Acid, 9, 12-Hexadecadienoic Acid (16:2 n-4), in Animal Cell Cultures
- OJ-203 Systemic and Virtual Histological Determinant Factors of Coronary Distensibility(OJ34,Atherosclerosis (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-338 Relationship between coronary artery distensibility and plaque composition determined by Virtual Histology-IVUS(Intravascular endoscopy/Intravascular ultrasound(06)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-005 Longitudinal Inhomogeneity of Coronary Distensibility in Acute Coronary Syndrome Related Plaques(Acute coronary syndrome, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-777 IVUS Reduces Restenosis Rate after Bare-Metal Stenting in Patients with Acute Myocardial Infarction(Intravascular endoscopy/Intravascular ultrasound-7 (I) PJ135,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PE-369 Parameters of Cardiac Dyssynchrony Predicts Chronic Cardiac Function after Acute Myocardial Infarction(Echo/Doppler-9 (I) PE62,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Real-time 3D Echo Cardiac Wall Motion Dyssyncrony Reflect Cardiac Function in Patients of Acute Myocardial Infarction(Echo/Doppler 1 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-071 Inhomogeneous Coronary Compliance Is Related to Plaque Vulnerability(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- The Effects of Maternal Mild Protein Restriction on Stroke Incidence and Blood Pressure in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)
- Competitive Incorporation of Arachidonic Acid Analogs by Cultured Rat Keratinocytes
- Cell Age Distribution of Erythrocytes at the Incidence of Cerebral Stroke in Stroke-Prone Spontaneously Hypertensive Rats, and Their Glutathione Peroxidase Activity
- Site-directed mutagenesis of possible catalytic residues of cellobiose 2-epimerase from Ruminococcus albus
- Cloning and Heterologous Expression of a β-Fructofuranosidase Gene from Arthrobacter globiformis IFO 3062, and Site-Directed Mutagenesis of the Essential Aspartic Acid and Glutamic Acid of the Active Site (ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHN
- Cloning and Heterologous Expression of a Glucodextranase Gene from Arthrobacter globiformis I42, and Experimental Evidence for the Catalytic Diad of the Recombinant Enzyme(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Cloning of a Gene Cluster Responsible for the Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α
- A Wound-Inducible Tobacco Peroxidase Gene Expresses Preferentially in the Vascular System
- 1-Aminocyclopropane-1-carboxylate Synthase of Penicillium citrinum : Primary Structure and Expression in Escherichia coli and Saccharomyces cerevisiae(Biochemistry & Molecular Biology)
- Major Isoforms of Starch Branching Enzymes in Premature Seeds of Kidney Bean (Phaseolus vulgaris L.)
- A Large Family of Class III Plant Peroxidases
- A UNIQUE TOBACCO PEROXIDASE GENE TPOXN1 IS EXPRESSED IN VASCULAR AND EPIDERMAL SYSTEMS FOR A LONG TIME
- 1-Aminocyclopropane-1-carboxylate (ACC) Deaminase Induced by ACC Synthesized and Accumulated in Penicillium citrinum Intracellular Spaces
- Wound-Induced Expression of a Tobacco Peroxidase Is Not Enhanced by Ethephon and Suppressed by Methyl Jasmonate and Coronatine
- Expression profile of a wound-induced tobacco peroxidase gene
- Purification and Properties of Extracellular Carboxyl Proteases of Acid-tolerant Bacteria, Isolated from Compost
- Molecular Cloning of Isomaltotrio-dextranase Gene from Brevibacterium fuscum var. dextranlyticum strain 0407 and Its Expression in Escherichia coli
- Properties, Sequence, and Synthesis in Escherichia coli of 1-Aminocyclopropane-1-Carboxylate Deaminase from Hansenula saturnus
- Diterpene Cyclases Responsible for the Biosynthesis of Phytoalexins, Momilactones A, B, and Oryzalexins A-F in Rice
- Cloning and Sequencing of a cDNA Encoding α-Glucosidase from Sugar Beet
- Substitutions of Alanine for Cysteine at a Reactive Thiol Site and for Lysine at a Pyridoxal Phosphate Binding Site of 1-Aminocyclopropane-1-carboxylate Deaminase
- ANALYSIS OF WOUND RESPONSE MEDIATED BY 5' -FLANKING REGION OF RICE PEROXIDASE GENE
- Molecular Cloning and Nucleotide Sequences of cDNA and Gene Encoding endo-Inulinase from Penicillium purpurogenum
- Chemical Modification and Amino Acid Sequence of Active Site in Sugar Beet α-Glucosidase
- New Method of Estimating Myocardial Infarct Size Using Technetium-99m Pyrophosphate and Thallium-201 Dual Single Photon Emission Computed Tomography Imaging
- Effects of Angiotensin I-Converting Enzyme Inhibitor from Ashitaba (Angelica keiskei) on Blood Pressure of Spontaneously Hypertensive Rats
- Effect of cyanocobalamin and p-toluic acid on the fatty acid composition of Schizochytrium limacinum (Thraustochytriaceae, Labyrinthulomycota)
- Horseradish Peroxidase Degrades Lipid Hydroperoxides and Suppresses Lipid Peroxidation of Polyunsaturated Fatty Acids in the Presence of Phenolic Antioxidants(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- High-level Secretion of a Rhizopus niveus Aspartic Proteinase in Saccharomyces cerevisiae(Microbiology & Fermentation Industry)
- Differential Chain-Length Specificities of Two Isoamylase-Type Starch-Debranching Enzymes from Developing Seeds of Kidney Bean
- Formation of a Novel Odd Chain Polyunsaturated Fatty Acid, 5,8,11,14,17-cis-Nonadecapentaenoic Acid, by an EPA-Producing Aquatic Fungus, Saprolegnia sp.28YTF- 1
- Synthesis of 2-Deoxy-glucooligosaccharides through Condensation of 2-Deoxy-D-glucose by Glucoamylase and α-Glucosidase
- Expression profiles of genes for two novel tobacco peroxidases induced by mechanical wounding and during local lesion formation following TMV infection
- Glucoamylase Produced by Rhizopus and by a Recombinant Yeast Containing the Rhizopus Glucoamylase Gene(Biological Chemistry)
- The N-terminal region of the starch-branching enzyme from Phaseolus vulgaris L. is essential for optimal catalysis and structural stability
- Characterization of Starch Synthase I and II Expressed in Early Developing Seeds of Kidney Bean (Phaseolus vulgaris L.)
- Experimental and Clinical Studies on Prognosis-Deteriorating Factors in the Acute Stage of Intraventricular Hemorrhage
- EFFECTS OF DIGOXIN AND β-BLOCKING AGENT ON THE HEART RATE IN PATIENTS WITH ATRIAL FIBRILLATION : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
- Differential Chain-Length Specificities of Two Isoamylase-Type Starch-Debranching Enzymes from Developing Seeds of Kidney Bean
- Learning abilities in SHR and SHRSP in various water maze tasks
- EFFECTS OF THE NEONATAL VITAMIN A EXPOSURE ON BEHAVIORS OF ADULT RATS
- Effects of the Neonatal Vitamin a Exposure on Behaviors of Adult Rats
- Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats
- Prediction of Stroke Lesions in Stroke-prone Spontaneously Hypertensive Rats by Glutathione Peroxidase in Erythrocytes
- Purification and Some Properties of a Trehalase from a Green Alga, Lobosphaera sp.
- Long-Term Survival After a Surgical Resection of Pulmonary Metastases from Gastric Cancer : Report of a Case
- Electron Microscopic Study of Ventricular Wall and Choroid Plexus in Experimentally-Induced Hydrocephalic Dogs
- Comparison of Enzymatic Properties and Gene Expression Profiles of Two Tuberonic Acid Glucoside β-Glucosidases from Oryza sativa L.
- Inhibitory Effects of Whisky Polyphenols on Melanogenesis in Mouse B16 Melanoma Cells
- Suppressive Action of Docosahexaenoic Acid Enriched-Euglena on Reduction of Endothelium-Dependent Relaxation in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP).
- Bail-Out of Drug-Refractory VF Electrical Storm in a Patient Who Underwent Percutaneous Coronary Intervention for Three Vessel Disease
- Search for Promotion Factors of Ultrasound Bone Measurement in Japanese Males and Pre/Post-Menarcheal Females Aged 8-14 Years
- Successful Ablation of Persistent Atrial Fibrillation Starting from Firing of Superior Vena Cava after Ablation of Complex Fractionated Atrial Electrograms
- Chemotherapy-Induced Arrhythmia Which Was Wide QRS Tachycardia Derived from Supra Vena Cava, Atrial Flutter, and Atrial Fibrillation with Syncope
- Increase in Tpeak–Tend interval induced by cardiac resynchronization therapy is a predictor of ventricular tachyarrhythmia
- Long-term effectiveness of right septal pacing vs. right apical pacing in patients with atrioventricular block
- The Long-Term Effectiveness of Right Ventricular Pacing at Different Sites Using Rotation, Torsion and Tei Index
- Clinical Characteristics and Predicting Factors of Electrical Storm in Patients with Ischemic Heart Disease and Left Ventricular Dysfunction
- Functional Changes of Erythrocytes at Cerebral Stroke in Stroke Prone Spontaneously Hypertensive Rats
- Fundus and Histopathological Changes in SHRSP after Administration of Antihypertensive Agents-A Comparison of Nifedipine and Captopril
- Fundus and Histopathological Changes in SHRSP after Administration of Three Kinds of Antihypertensive Agents and Ascorbic acid:A Comparison of Ca-channel blocker, β-blocker, ACEI and V-C
- Influence of Episesamin on Lipoprotein Metabolism in Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Dietary Docosahexaenoic Acid Intake During Gestation and Lactation Period and the Open Field Activity and the Holeboard Exploratory Performance of Stroke-prone Spontaneously Hypertensive Rat
- Effect of Episesamin on Lipoprotein Metabolism in Normocholesterolemic Stroke-Prone SHR (SHRSP)
- Effect of Chronic Alcohol Consumption on Blood Pressure, Cerebral Stroke Lesions, Body Weight and Life-span in SHRSP
- Effects of Oxidative Stress on Vascular Reactivity in the Offspring of Protein-Restricted Stroke-Prone Spontaneously Hypertensive Rats
- Geometric Structure and Formation Condition of Corded Isolated-Mixing Region in Impeller Agitated Vessel
- Effect of Buckwheat Protein Extract on Lipid Metabolism in Diet-Induced Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Vitamin E Improves Cholesterol Metabolism in Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Effect of Feeding Fish Diet from the Hypertensive Stage on the ACE Activity in Serum and Vascular in SHRSP
- Effect of Sesamin on Lipid Metabolism in SHRSP Fed Safflower Oil Fatty Acids as a Lipid Source
- Ordinary Autonomic Unbalance Can Reflect Diagnosis of Neurally Mediated Reflex Syncope