C19 Odd-chain Polyunsaturated Fatty Acids (PUFAs) Are Metabolized to C21-PUFAs in a Rat Liver Cell Line, and Curcumin, Gallic Acid, and Their Related Compounds Inhibit Their Desaturation

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概要

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• It was demonstrated that the rat liver cell line BRL-3A converted exogenous C19 odd chain-polyunsaturated fatty acids (PUFAs) into the corresponding C21-and C23-PUFAs as follows : 21 : 3n-8,21 : 4n-8,23 : 3n-8,and 23 : 4n-8 (from 19 : 3n-8) ; 21 : 4n-5,21 : 5n-5,23 : 4n-5,and 23 : 5n-5 (from 19 : 4n-5) ; 21 : 5n-2,21 : 6n-2,23 : 5n-2,and 23 : 6n-2 (from 19 : 5n-2). It presumed that these C19 PUFAs were converted through the mimic route to docosa-hexaenoic acid (22 : 6n-3) from eicosapentaenoic acid (20 : 5n-3). In addition, the characterization of the change of fatty acid composition of cellular lipids in rat liver cells were examined, using 19 : 4n-5 and several fatty acid desaturation inhibitors. Curcumin related compounds, curcumin, capsaicin, isoeugenol, 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, and gallic acid esters with near five carbon numbered alcohol had great changes of fatty acid composition of cellular lipids based on inhibition of the ⊿6 desaturation of C24-PUFAs in rat liver cells.

• 社団法人日本農芸化学会の論文
• 2000-08-23

著者

• Shimizu Sakayu

  Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University

• Shimizu Sakayu

  Division Of Applied Life Science Graduate School Of Agriculture Kyoto University

• SHIRASAKA Norifumi

  Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University

• YOSHIZUMI Hajime

  Department of Food and Nutrition, Faculty of Agriculture, Kinki University

• MURAKAMI Tetsuo

  Department of Food and Nutrition, Faculty of Agriculture, Kinki University

• NAKANO Nobuhiro

  Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University

• KOYAMA Hiroko

  Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University

• HINO Miki

  Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University

• Shirasaka N

  Kinki Univ. Nara Jpn

• Shirasaka Norifumi

  Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University

• Shirasaka Norifumi

  近畿大学 農学部

• Shirasaka Norifumi

  Department Of Agricultural Chemistry Kyoto University

• Hino Miki

  Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University

• Koyama Hiroko

  Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University

• Koyama Hiroko

  Department Of Chemistry And Research Center For Materials Science Nagoya University

• NAKANO Nobuhiro

  Atopy (Allergy) Research Center, Juntendo University School of Medicine

• Nakano Nobuhiro

  Atopy (allergy) Research Center Juntendo University School Of Medicine

• Nakano Nobuhiro

  Department Of Dermatology Atopy Research Center Juntendo University School Of Medicine

• Yoshizumi Hajime

  Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University

• Yoshizumi Hajime

  Institute For Fundamental Research Research Center

• Yoshizumi Hajime

  Kinki University

• Yoshizumi Hajime

  Department Of Food And Nutrition Faculty Of Agriculture Kin-ki University

• Matsuo Takuya

  First Department Of Anatomy Kinki University School Of Medicine

• Matsuo Takuya

  Department Of Food Science And Nutrition Faculty Of Agriculture Kinki University

• MURAKAMI Tetsuo

  Department of Food and Nutrition Faculty of Agriculture Kinki University

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