Effects of Oxidative Stress on Vascular Reactivity in the Offspring of Protein-Restricted Stroke-Prone Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Oxidative stress was induced in 12-week-old offspring of protein-restricted (9% protein) and control (20% protein) protein-restricted stroke-prone spontaneously hypertensive rats (SHRSP) by administering phorbol 12-myristate 13-acetate (PMA) for 4 weeks to determine the effects of oxidative stress on the vascular function of the SHRSP offspring. There was no significant difference in the blood pressure of offspring of the protein-restricted dams and control dams. The plasma diacron-reactive oxygen metabolite (dROM) level at 16 weeks of age was significantly higher in offspring of the protein-restricted dams, whereas the anti-oxidative enzyme activity was similar in both groups. Acetylcholine (Ach)-induced relaxation was significantly reduced in offspring of the protein-restricted dams. The expression of endothelial nitric oxide synthase (eNOS) was lower and the expression of soluble guanylic acid cyclase (sGC) was higher in offspring of the protein-restricted dams. These results indicate that SHRSP offspring of the protein-restricted dams were sensitive to oxidative stress, and displayed the vascular dysfunction.
著者
-
MURAKAMI Tetsuo
Department of Food and Nutrition, Faculty of Agriculture, Kinki University
-
TAHARA Aki
Department of Biological and Environmental Engineering, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
TAKEMORI Kumiko
Department of Food and Nutrition, Kinki University Faculty of Agriculture
-
TAHARA Aki
Department of Food and Nutrition, Kinki University Faculty of Agriculture
-
KOMETANI Takashi
Department of Food and Nutrition, Kinki University Faculty of Agriculture
-
MURAKAMI Tetsuo
Department of Food and Nutrition, Kinki University Faculty of Agriculture
-
MURAKAMI Tetsuo
Department of Food and Nutrition Faculty of Agriculture Kinki University
関連論文
- Microbial Synthesis of trans Isomer of Eicosapentaenoic Acid (EPA) from the Chemically Synthesized Trans Isomer of Linolenic Acid by a Δ12 Desaturase-defective Mutant of Mortierella alpina 1S-4(Microbiology & Fermentation Technology)
- Inhibitory Effects of Capsaicinoids on Fatty Acid Desaturation in a Rat Liver Cell Line(Food & Nutrition Science)
- C19 Odd-chain Polyunsaturated Fatty Acids (PUFAs) Are Metabolized to C21-PUFAs in a Rat Liver Cell Line, and Curcumin, Gallic Acid, and Their Related Compounds Inhibit Their Desaturation
- Formation of 8, 11, 14-Octadecatrienoic Acid (18:3 n-4) from Naturally Occurring Unique Fatty Acid, 9, 12-Hexadecadienoic Acid (16:2 n-4), in Animal Cell Cultures
- The Effects of Maternal Mild Protein Restriction on Stroke Incidence and Blood Pressure in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)
- Competitive Incorporation of Arachidonic Acid Analogs by Cultured Rat Keratinocytes
- Cell Age Distribution of Erythrocytes at the Incidence of Cerebral Stroke in Stroke-Prone Spontaneously Hypertensive Rats, and Their Glutathione Peroxidase Activity
- Effects of Angiotensin I-Converting Enzyme Inhibitor from Ashitaba (Angelica keiskei) on Blood Pressure of Spontaneously Hypertensive Rats
- Experimental and Clinical Studies on Prognosis-Deteriorating Factors in the Acute Stage of Intraventricular Hemorrhage
- Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats
- Prediction of Stroke Lesions in Stroke-prone Spontaneously Hypertensive Rats by Glutathione Peroxidase in Erythrocytes
- Electron Microscopic Study of Ventricular Wall and Choroid Plexus in Experimentally-Induced Hydrocephalic Dogs
- Suppressive Action of Docosahexaenoic Acid Enriched-Euglena on Reduction of Endothelium-Dependent Relaxation in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP).
- Search for Promotion Factors of Ultrasound Bone Measurement in Japanese Males and Pre/Post-Menarcheal Females Aged 8-14 Years
- Functional Changes of Erythrocytes at Cerebral Stroke in Stroke Prone Spontaneously Hypertensive Rats
- Fundus and Histopathological Changes in SHRSP after Administration of Antihypertensive Agents-A Comparison of Nifedipine and Captopril
- Fundus and Histopathological Changes in SHRSP after Administration of Three Kinds of Antihypertensive Agents and Ascorbic acid:A Comparison of Ca-channel blocker, β-blocker, ACEI and V-C
- Influence of Episesamin on Lipoprotein Metabolism in Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Dietary Docosahexaenoic Acid Intake During Gestation and Lactation Period and the Open Field Activity and the Holeboard Exploratory Performance of Stroke-prone Spontaneously Hypertensive Rat
- Effect of Episesamin on Lipoprotein Metabolism in Normocholesterolemic Stroke-Prone SHR (SHRSP)
- Virus Vector-Mediated Rapid Protein Production in Nicotiana benthamiana : Effects of Temperature and Photosynthetic Photon Flux Density on Hemagglutinin Accumulation
- Effect of Chronic Alcohol Consumption on Blood Pressure, Cerebral Stroke Lesions, Body Weight and Life-span in SHRSP
- Effects of Oxidative Stress on Vascular Reactivity in the Offspring of Protein-Restricted Stroke-Prone Spontaneously Hypertensive Rats
- Effect of Buckwheat Protein Extract on Lipid Metabolism in Diet-Induced Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Vitamin E Improves Cholesterol Metabolism in Hypercholesterolemic Stroke-Prone SHR (SHRSP)
- Effect of Feeding Fish Diet from the Hypertensive Stage on the ACE Activity in Serum and Vascular in SHRSP
- Effect of Sesamin on Lipid Metabolism in SHRSP Fed Safflower Oil Fatty Acids as a Lipid Source