Three Automated Feeding Strategies of Natural Complex Nutrients Utilizing On-Line Turbidity Values in Fed-Batch Culture : A Case Study on the Cultivation of a Marine Microorganism
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概要
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A comparison of three automated feeding strategies was made utilizing on-line turbidity values in fed-batch cultures. Control indices in these feeding strategies were (i) total cell mass (VX), (ii) total cell mass (VX) and estimated cell yield on the basis of the total amount of the substrate supplied (Y_<x/ins>), and (iii) growth rate(d(VX)/dt). A marine microorganism, Alteromonas putrefaciens, was cultivated by feeding a solution composed of peptone (220 g/l) and yeast extract (110 g/l). When the automatic feeding strategy (i) was applied, a considerable amount of peptide accumulated in the later phase, indicating 'overfeeding' of the natural complex nutrients. The improved feeding strategies (ii) and (iii) enabled the overfeeding to be avoided, resulting in more effective utilization of the nutrients fed. Overall, the maximum cell concentrations were increased more than 1.5 times, while the total amounts of nutrients fed were reduced by a half.
- 公益社団法人日本生物工学会の論文
- 1993-06-25
著者
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Yamane Tsuneo
Laboraotory Of Bioreaction Engineering Department Of Food Science And Technology Faculty Of Agricult
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Yamane Tsuneo
Laboratory Of Bioreaction Engineering Department Of Food Science And Technology School Of Agricultur
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Miyaoku Kohei
Department Of Synthetic Chemistry And Biological Chemistry Graduate School Of Engineering Kyoto Univ
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Miyamoto K
Faculty Of Pharmaceutical Sciences Osaka University
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KADOTANI YASUYUKI
Central Engineering & Construction Co. Ltd.
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KOMINAMI MINORU
Central Engineering & Construction Co. Ltd.
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Kadotani Yasuyuki
Central Engineering & Construction Co. Ltd.
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Yamane Tsuneo
Laboratory Of Molecular Biotechnology Graduate School Of Bio- And Agro-sciences Nagoya University
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HIBINO WATARU
Laboratory of Molecular Biotechnology, Department of Applied Biological Sciences, Faculty of Agricul
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Hibino Wataru
Laboratory Of Molecular Biotechnology Department Of Applied Biological Sciences Faculty Of Agricultu
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