Oxidative Resolution with Baker's Yeast for Large-Scale Production of Chiral 1,2-Alkanediols

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概要

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• We studeid oxidative resolution with baker's yeast for the larga-scale perparation of chiral 1,2-alkanediol.First, we estimated the outline of the enantioselective oxidaton, especially in relation to oxygen transfer, form the transformation of (R)-1,2-propanediol to acetol. In this yeast mediated oxidation, we found that 1.7 mol of acetol was produced with consumption of 1 mol of oxygen (85% efficiency). The oxidation rate per gram of bake' yeast was correlated to the product of k_Lα, controlled by changing the concentration of bakers's yeast and/or the agitation rate, and p_<o2>. It increased with increasing k_Lα・p_<o2>, then became constant at a value above 100 atm/h. Treatment of racemic 1,2-propanediol, -butanediol, or -pentanediol in a 19-l bubble-column reactor afforeded mixtures of the crresponding (S)-1,2-aslanediols with about 79% enatiomeric excess and the corresponding 1-hydroxy-2-alkanones. The latter were ezsily separated as an aqueous solution, that was directly used in the bakers' yeast-mediated bioreduction to prepare (R)-1,2-alkanediols.

• 社団法人日本生物工学会の論文
• 1995-08-25

著者

• KOMETANI Tadashi

  Department of Chemical and Biochemical Engineering

• YOSHII Hidefumi

  Department of Biotechnology, Tottori University

• MATSUNO RYUICHI

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Yoshii H

  Tottori Univ. Tottori Jpn

• MORITA Yasufumi

  Department of Chemical and Biochemical Engineering, Toyama National College of Technology

• Morita Yasufumi

  Department Of Chemical And Biotechemical Engineering Toyama National College Of Tehcnology

• Morita Yasufumi

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• Kobayashi T

  Kyoto Univ. Kyoto Jpn

• KIYAMA YOSHIAHRU

  Department of Chemical and Biochemical Engineering, Toyama National College of Technology

• Kometani Tadashi

  Department Of Biochemical Engineering Toyama National College Of Technology

• Morita Y

  Shinshu Univ. Nagano Jpn

• Yoshii Hidefumi

  Department Of Applied Biological Science Kagawa University

• Kiyama Yoshiahru

  Department Of Chemical And Biochemical Engineering Toyama National College Of Technology

• Matsuno Ryuichi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Matsuno Ryuichi

  Deparment Of Food Science And Technology Faculty Of Agriculture Kyoto University

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