Interaction of Modified Cyclodextrins with Cytochrome P-450

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概要

• 論文の詳細を見る

• The effects of modified cyclodextrins (CDs) hydroxypropyl-β-CD and methyl-β-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-β-CD inhibited CYP1A2 and CYP2D6 at higher concentrations.

• 社団法人 日本農芸化学会の論文
• 2005-01-23

著者

• YOSHII Hidefumi

  Department of Biotechnology, Tottori University

• FURUTA Takeshi

  Department of Biotechnology, Tottori University

• Yoshii Hidefumi

  Department Of Biotechnology Faculty Of Engineering Tottori University

• Yoshii Hidefumi

  Department Of Biochemical Engineering Toyama National College Of Technology

• Furuta Takeshi

  Department Of Biotechnology Faculty Of Engineering Tottori University

• Ishikawa M

  Department Of Biotechnology Faculty Of Engineering Tottori University

• ISHIKAWA Minoru

  Department of Biotechnology, Faculty of Engineering, Tottori University

• Ishikawa Minoru

  Department Of Applied Physics. Faculty Of Engineering University Of Tokyo

• Yoshii Hidefumi

  Department Of Applied Biological Science Kagawa University

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