Cucurbitane-Type Triterpenes with Anti-proliferative Effects on U937 Cells from an Egyptian Natural Medicine, Bryonia cretica: Structures of New Triterpene Glycosides, Bryoniaosides A and B
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概要
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The 90% aqueous ethanol extract of an Egyptian natural medicine, the roots of Bryonia cretica L., was found to exhibit a strong inhibitory effect on the proliferation of human leukemia U937 cells. By bioassay-guided fractionation, we isolated two new cucurbitane-type triterpene glycosides, bryoniaosides A and B, were isolated from the roots of Bryonia cretica L. together with 16 known cucurbitane-type triterpenes and glycosides. The chemical structures of bryoniaosides A and B were determined on the basis of chemical and spectroscopic evidence. Effects of principal cucurbitane-type triterpenes (cucurbitacins B, D, E, and J, 23,24-dihydrocucurbitacins B and E, and hexanorcucurbitacin D) on proliferation of the cells were examined. Cucurbitacins B and E showed the greater cytotoxic effects with IC50 values of 9.2 and 16 nM after 72 h, and their IC50 values were equivalent to that of camptothecin. An α,β-conjugated ketone moiety at the 22—24-positions and an acetoxy group at the 25-position are essential for the strong activity.
- 公益社団法人 日本薬学会の論文
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Pharmaceutical Research and Technology Institute, Kinki University
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda H
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Nakashima Souichi
Kyoto Pharmaceutical University
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Abdel-Halim Osama
College of Pharmacy, Taibah University
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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