Medicinal Foodstuffs. XXIX. Protective Effects of Sesquiterpenes and Curcumin from Zedoariae Rhizoma on Liver Injury Induced by D-Galactosamine / Lipopolysaccharide or Tumor Necrosis Factor-α
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概要
- 論文の詳細を見る
The 80% aqueous acetone extract of Zedoariae Rhizoma was found to show a protective effect against D-galactosamine (D-GaIN)/lipopolysaccharide-induced acute liver injury in mice. To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, dehydrocurdione, germacrone, 13-hydroxygermacrone, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone) and a diarylheptanoid (curcumin) were found to inhibit the increase in serum aspartate aminotransaminase and alanine aminotransaminase at a dose of 50 mg/kg p.o. in agreement with the previous in vitro studies, except for dehydrocurdione, aerugidiol, and zedoarondiol. In particular, curdione, neocurdione, curcumenol, and isocurcumenol potently inhibited the increase at a dose of 12.5 mg/kg p.o. Furthermore, the eight sesquiterpenes, furanodiene, curdione, neocurdione, dehydrocurdione, germacrone, 13-hydroxygermacrone, curcumenol, and curcumenone, also showed a protective effect against D-GaIN/tumor necrosis factor-α-induced liver injury in mice at a dose of 50mg/kg p.o.
- 公益社団法人日本薬学会の論文
- 2002-05-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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NINOMIYA Kiyofumi
Kyoto Pharmaceutical University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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