Bioactive Saponins and Glycosides. XVI. Nortriterpene Oligoglycosides with Gastroprotective Activity from the Fresh Leaves of Euptelea polyandra SIEB. et ZUCC. (1) : Structures of Eupteleasaponins I, II, III, IV, V, and V Acetate

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The saponin fraction from the fresh leaves of Euptelea polyandra SIEB. et ZUCC. was found to exhibit potent gastroprotective activity. Fourteen new nortriterpene saponins called eupteleasaponins were isolated from the saponin fraction with gastroprotective activity. The structures of eupteleasaponins I, II, III, IV, V, and V acetate were determined on the basis of chemical and physicochemical evidence as 3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl(1→3)-β-D-xylopyranosylakebonoic acid 28-O-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→4)]-β-D-glucopyranosyl(1→3)-β-D-xylopyranosylakebonoic acid 28-O-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl(1→2)-[α-L-arabinopyranosyl(1→4)-α-L-rhamnopyranosyl(1→4)]-β-D-glucopyranosyl(1→3)-β-D-xylopyranosylakebonoic acid 28-O-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl(1→2)-[α-L-arabinopyranosyl(1→4)-α-L-rhamnopyranosyl(1→4)]-β-D-glucopyranosyl(1→3)-β-D-xylopyranosylakebonoic acid, 3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyleupteleogenin, and 3-O-α-L-rhamnopyranosyl(1→2)-6"-O-acetyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyleupteleogenin.
公益社団法人日本薬学会の論文
2000-07-01