Protective Effects of Polygodial on Gastric Mucosal Lesions Induced by Necrotizing Agents in Rats and the Possible Mechanisms of Action
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概要
- 論文の詳細を見る
The effects of polygodial isolated from the leaves of Tasmannia lanceoiata on necrotizing agents-induced gastric lesions in rats were compared with capsaicin. Polygodial markedly inhibited the gastric mucosal lesions induced by several necrotizing agents, such as ethanol (ED_<50>=0.029mg/kg, P.O.), 0.6_M HCI (ED_<50>=0.26mg/kg, P.O.), and aspirin (ED_<50>=0.38 mg/kg, p.o.), and partly inhibited the gastric mucosal lesions induced by indomethacin, but showed no significant effect on acid output in pylorus-ligated rats at doses of 0.05-0.5 mg/kg. The gastroprotection of polygodial was attenuated by pretreatment with indomethacin (10 mg/kg, s.c.), N^G-nitro-L-arginine methyl ester (70 mg/kg, I.p.), N-ethylmaleimide (10 mg/kg, s.c.) and ruthenium red (3.5 mg/kg, s.c.). Polygodial (0.2 mg/kg, p.o.) increased the amount of reduced glutathione in gastric mucosa of ethanol-treated group. These results suggested that endogenous prostaglandins, nitric oxide, sulfhydryl compounds and vanilloid receptor-mediated effects are involved in the protective effect of polygodial.
- 公益社団法人日本薬学会の論文
- 2003-05-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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ASAO Yasunobu
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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PONGPIRIYADACHA Yutana
Kyoto Pharmaceutical University
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Asao Y
Kyoto Pharmaceutical University
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Pongpiriyadacha Yutana
Fac. Of Sci. And Technol. Rajamangala Univ. Of Technol. Srivijaya
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MATSUDA HISASHI
Kyoto College of Pharmacy
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