茶カテキン-大豆タンパク質複合体がラットの脂質代謝に及ぼす効果

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The effects of the addition on the complex of tea catechins and soybean protein (the complex), a new food material, on lipid metabolism in the plasma and liver of rats with or without cholesterol diets were studied. Body weight gain, food intake, food efficiency, liver weight, and lipid concentrations were not influenced by the addition of the complex in rats without cholesterol diets. In rats with cholesterol diets, the complex also showed no remarkable influence on growth factors, liver weight, or phospholipid levels, and unfavorable symptoms were not observed at the ingestion of the complex. The addition of soybean protein decreased plasma triglyceride levels, but the addition of the complex decreased these levels more than did soybean protein. The tea catechin and soybean protein in the complex would collaboratively contribute to decrease the plasma and liver triglyceride levels in rats with cholesterol diets. The complex also decreased total plasma cholesterol levels but showed no effect on the liver. Furthermore the complex suppressed thiobarbituric acid reactive substances (TEARS) levels in the plasma and liver. Thus, some part of the tea catechin, especially (-)-epigallocatechin 3-0-gallate (EGCG) and (-)-epicatechin 3-0-gallate (ECG), in the complex was metabolized and showed antioxidant activity. In addition, the complex showed no significant effect on the fecal excretion of neutral steroids and bile acid. These results indicate that accumulation of plasma triglyceride, cholesterol, and TBARS, and liver triglyceride and TEARS are prevented and amended by the ingestion of the complex under a cholesterol-loading diet.
2004-09-28

茶カテキン-大豆タンパク質複合体がラットの脂質代謝に及ぼす効果

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