Hypothesis : Structures, Evolution, and Ancestor of Glucose Kinases in the Hexokinase Family
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概要
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Glucose kinase, which we tentatively use in this review, represents the enzymes catalyzing the phosphorylation of glucose and other hexoses by means of phosphoryl donors (ATP, ADP, and inorganic polyphosphate [poly(P)]). Except for glucose kinases utilizing ADP, all other glucose kinases belong to the hexokinase (HK) family and are classified into three groups based on primary structural information, i.e., groups HK, A, and B. The structural and evolutionary relationships of glucose kinases belonging to the above three groups have been controversial due to the lack of tertiary structural information on those in groups A and B. However, recent studies on the tertiary structures of poly(P)/ATP-glucomannokinase (GMK : a glucose kinase in group B) from Arthrobacter sp. strain KM and glucokinase (GK) (ecoGK : a glucose kinase in group A) from Escherichia coli have shed light on this problem. A comparison of the tertiary structures of GMK and ecoGK with those of glucose kinases in group HK demonstrated that both GMK and ecoGK are structurally homologous with glucose kinases in group HK, and that glucose kinases belonging to groups HK, A, and B in the HK family evolved divergently from a common ancestor. Based on the simple structure of GMK compared to those of ecoGK and glucose kinases in group HK, and the putative poly(P)-binding site in GMK, we propose that the ancestor of glucose kinases in the HK family was similar to GMK and used poly(P). We also discuss the ancestor and evolutionary process of ROK proteins, whose primary structures are homologous with those of glucose kinases in group B, in connection with the ancestor and evolutionary process of glucose kinases in the HK family.
- 社団法人日本生物工学会の論文
- 2005-04-25
著者
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Mikami B
Kyoto Univ. Kyoto Jpn
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Mikami Bunzo
Graduate School Of Agriculture Kyoto Univ.
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Mikami Bunzo
Laboratory Of Food Quality Design And Development Graduate School Of Agriculture Kyoto University
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Murata K
Dep. Of Basic And Applied Molecular Biotechnology Div. Of Food And Biological Sci. Graduate School O
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Murata Kousaku
Div. Of Food Sci. And Biotech. Grad. Sch. Of Agriculture Kyoto Univ.
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MORI SHIGETAROU
Department of Basic and Applied Molecular Biotechnology, Division of Food and Biological Science, Gr
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KAWAI SHIGEYUKI
Department of Basic and Applied Molecular Biotechnology, Division of Food and Biological Science, Gr
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MURATA KOUSAKU
Department of Basic and Applied Molecular Biotechnology, Division of Food and Biological Science, Gr
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MUKAI TAKAKO
Department of Basic and Applied Molecular Biotechnology, Division of Food and Biological Science, Gr
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Kawai Shigeyuki
Dep. Of Basic And Applied Molecular Biotechnology Div. Of Food And Biological Sci. Graduate School O
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Matsushita Kazunobu
Derartment Of Blological Chemistry Faculty Of Agriculture Yamaguchi University
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Mikami B
Kyoto Univ.
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Murata Kousaku
Dep. Of Basic And Applied Molecular Biotechnology Div. Of Food And Biological Sci. Graduate School O
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Momma Keiko
Laboratory Of Basic And Applied Molecular Biotechnology Graduate School Of Agriculture Kyoto Univers
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Mukai T
Department Of Basic And Applied Molecular Biotechnology Division Of Food And Biological Science Grad
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Matsushita K
Department Of Biological Chemistry Faculty Of Agriculture Yamaguchi University
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Mori Shigetarou
Department Of Basic And Applied Molecular Biotechnology Division Of Food And Biological Science Grad
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Kawai Shigeyuki
Laboratory Of Basic And Applied Molecular Biotechnology Graduate School Of Agriculture Kyoto Univers
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Kawai Shigeyuki
Department Of Basic And Applied Molecular Biotechnology Division Of Food And Biological Science Grad
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Murata Kousaku
Department Of Basic And Applied Molecular Biotechnology Division Of Food And Biological Science Grad
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Mikami Bunzo
Div. Of Food Sci. And Biotechnology Graduate School Of Agriculture Kyoto Univ.
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松下 一信
山口大 農
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Mikami Bunzo
Laboratory of Applied Structural Biology, Division of Applied Life Science, Graduate School of Agriculture, Kyoto University
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MORI Shigetarou
Department of Bacteriology II, National Institute of Infectious Diseases
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