Thermolysin-Catalyzed Synthesis of Peptide Amides
スポンサーリンク
概要
- 論文の詳細を見る
Enzymatic condensation by thermolysin between various amino acid amides and N^α-protected or unprotected peptides was examined. As models, three protected tetrapeptide amides, Boc-Trp-Met-Asp-X, Boc-Ser-Glu-Ala-X and Boc-Ser-Lys-Ala-X, and two unprotected tetrapeptide amides, H-Trp-Met-Asp-X and H-Phe-Met-Arg-X, were prepared [X=Phe-NH_2,Leu-NH_2,Phe-NHEt, Val-NH_2,Ala-NH_2,(p-fluoro)Phe-NH_2], and the effects of various experimental conditions (pH, solvent and time) were examined. In addition, the C-terminal of oxidized insulin B-chain was elongated to an amide by addition of various amides mentioned above with the aid of thermolysin.
- 公益社団法人日本薬学会の論文
- 1988-11-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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先名 淳
Kyoto Reseach Laboratories, Toho Pharmaceutical Ind. Co., Ltd.,
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森原 和之
Kyoto Research Laboratories Toho Pharmaceutical Ind. Co. Ltd.
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川面 佳子
Kyoto Research Laboratories, Toho Pharmaceutical Ind. Co., Ltd.,
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先名 淳
Kyoto Research Laboratories Toho Pharmaceutical Ind. Co. Ltd.
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川面 佳子
Kyoto Research Laboratories Toho Pharmaceutical Ind. Co. Ltd.
関連論文
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