REACTIVITY OF VASCULAR SMOOTH MUSCLE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

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By using the spiral strips of the thoracic aortas from male stroke-prone spontaneously hypertensive rats (SHRSP) and Kyoto Wistar rats (WKR) of one year old, effects of the modified contents of Na and Ca in medium on tonus and the contractile responses to K, noradrenaline, Ba and Ca were investigated.<BR>The application of Ca in medium produced the elevation of tonus with a dose - dependent manner in SHRSP, but no effect was found in WKR. The decrease of Ca in medium produced the decreased tonus. The rapid drop in tonus was slightly larger in SHRSP than in WKR, but the slow drop was larger in WKR than in SHRSP. The elevation of tonus by the decreased Na medium was larger in SHRSP than in WKR. The shape of contraction by Na removal from the medium was a lasting type without fade in SHRSP, while that in WKR was a transient type. The elevation of tonus by Na and Ca removal from medium was much smaller than that by Na removal in SHRSP, but there was no difference in WKR.<BR>The contractions by K, noradrenaline, Ba and Ca in SHRSP were larger than those in WKR, the contraction by Ca being more remarkable. The contractions by K and noradrenaline were reduced immediately after the exchange of medium to Ca - free one. The reduction was larger in SHRSP than in WKR. By the long time incubation in the Ca-free medium, the contractions by noradrenaline and Ba disappeared. The disappearance of the contraction by noradrenaline was faster in SHRSP than in WKR, but that of the contraction by Ba was almost the same.<BR>From these results, it may be suggested that Ca influx and Ca release are much accelerated in the blood vessel of SHRSP compared to that of WKR, which may be a cause of hypertension of SHRSP.
日本平滑筋学会の論文

REACTIVITY OF VASCULAR SMOOTH MUSCLE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

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