<基礎的研究発生病理>SHRSP, WKYの圧受容体反射機構の比較(2) : 急速脱血および生食水圧入時の変化

概要

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Disorders in the baroreceptor linked regulation of blood pressure may be a factor in spontaneously hypertensive rats (SHR), since an increase in threshold of baroreflex response has been shown in SHR. In order to study the baroreceptor system involved in blood pressure control, SHRSP and WKY, in age groups of 2-and 6-months, were subjected to the experiment. In the experiment, mean arterial blood pressure (BP) and heart rate (HR) were measured when blood volume was increased by saline (2.5ml/kg/5sec) addition and decreased by blood (2.5ml/kg/10sec) extraction. SHRSP 6 months old, in which blood extraction was undertaken, showed a greater decrease in BP in the fast response and a smaller increase in BP in the delayed response, than WKY and younger SHRSP. The results indicate that the baroreceptor system involved in BP control may work best in 2-month-old WKY, and may possibly be affected by hypertension in the aged SHRSP.
近畿大学の論文
1988-12-30