SHRSPおよびWKYの大動脈におけるSpare Receptor(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
Spare adrenaline and serotonin receptors were investigated in the isolated aortas from SHRSP and WKY. Dose-response (D-R) curves for the agonists, noradrenaline, phenylephrine, serotonin, were constructed in the absence of the irreversible antagonist, dibenamine, and then the D-R curves were repeatedly constructed in the presence of dibenamine until the D-R curves for agonists were shifted to the downward. The shifted distance to the right without the shift to the downward was calculated. From the results obtained, the spare receptor was calculated. The distances shifted in noradrenaline and phenylephrine were significantly less in SHRSP than in WKY, but that in serotonin was not different between the both. These results suggest that the spare adrenaline receptor in the aortas from SHRSP is less than that in WKY.
近畿大学の論文
1984-12-25