SHRSPの血液酸素運搬能と2.3DPG系について(I 発生病理)(A 基礎的研究)

概要

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Recent studies on hypertensive rats show that at low partial pressure of oxygen the survival rate of SHRSP is lower than WKY, and we have noted that the blood color of the aged SHRSP is more darkish than that of WKY when decapitated. Based on these observations, the present experiment has been designed to measure 2,3 DPG and 3 phosphoglycerate (3 PG) in erythrocytes and PO_2 in blood in view of the supplying capacity of oxygen to peripheral tissues. Because 2,3 DPG is one of the main factors which are concerned with the affinity of hemoglobin for oxygen, the following three possibilities are becoming apparent in SHRSP : 1) in both pulmonary and peripheral tissues the diffusion of oxygen may be prevented to some extent, 2) in peripheral tissues the less releasing of oxygen from hemoglobin may cause oxygen deficiency, and 3) the inability of producing 2,3 DPG may result in the decreased tolerance under oxygen deficiency, and the process of production of 2,3 DPG in SHRSP must have some defects. In addition to these results 2,3 DPG system in erythrocytes may be related to the progress of hypertension and to the tolerance under low partial pressure of oxygen.
近畿大学の論文
1981-09-25