SHRSP, WKYの圧受容体反射機構の比較

概要

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It is reported that hypertensive animal models such as SHR have disorders in baroreceptor reflex system. In this study, norphenephrine (1 mg/kg) and prazosin (0.1 mg/kg) were orally given to SHRSP and WKY, each of the age groups of 2- and 6-month-old and blood pressure (BP) and heart rate (HR) were measured. When prazosin was given to the SHRSP of 6 months old, BP widely fluctuated stepwise, which was apparently different in its manner com pared with WKY and younger SHRSP ; the primary fluctuation caused by the agent was large and the secondary one due to its reflex was small. In addition, 2-month-old WKY showed normal HR with wide fluctuation independent on the variation of BP. From these results, it is concluded that the baroreceptor system concerned with BP control may work best in 2-month-old WKY, but that in SHRSP its function may be impaired with aging, compared with that of younger SHRSP.
近畿大学の論文
1987-12-30