五苓散変方および柴苓湯の脳卒中易発症性高血圧自然発症ラット (SHRSP) における水代謝調節作用

概要

論文の詳細を見る
We studied chronic and sub chronic effects of Gorei-san analogue, Sairei-to or furosemide on the survival time and other physiological parameters in stroke prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar Kyoto rats (WKY). Total body water content and circulating plasma volume were extremely increased in SHRSP than WKY. But the effect of normalization on the body water distribution was found in the group given Gorei-san analogue or furosemide in SHRSP. Vasopressin level in urine was decreased in the group given Gorei-san analogue, but there was no effect in the group given furosemide in SHRSP. On the other hand, vasopressin level was reversed in WKY. Atrial natriuretic peptide (ANP) level in the plasma was increased in the group given Gorei-san analogue, but the same effect could not be found in the groups given Sairei-to or furosemide in SHRSP and WKY. Kampo medicines such as Gorei-san analogue and Sairei-to had no effect of survival time on the prolongation in SHRSP, but Gorei-san analogue might have the effect of body water distribution on the normalization in SHRSP.
和漢医薬学会の論文
2000-08-10