SHRSPのAntithrombin III活性について(A 基礎的研究)(I 発生病理)

概要

論文の詳細を見る
It has been well noted that SHRSP shows markedly high incidence of stroke as well as severe hypertension and that 80-90% of SHRSP died of the stroke within 6-9 months after birth. In this experiment, we measured the activity of antithrombin III (AT III) which may play a major role in antithrombin actions in blood and examined its relationship to aging. Although it can be seen from some observations that in male SHRSP, there were increasing activities of AT III with age reaching a peak on the age of high incidence of stroke, and that in female SHRSP, those of AT III were significantly higher compared with those of female WKR aged 3 to 9 months. There was no marked difference in level between male SHRSP and WKR. This leads us to conclude that there may be a certain correlation between higher values of AT III activity and the occurrence of stroke in its developmental course, but this high level of AT III may not be one of the major factors for the stroke. In addition, in the female of both SHRSP and WKR, higher levels of AT III would be due to the chronic effect of estrogen.
近畿大学の論文
1980-09-25