SHRSPとWKYの血小板凝集能における加齢による変化

概要

論文の詳細を見る
ADP- and collagen-induced platelet aggregation activities were measured in different age groups of SHRSP and the results were compared with those of WKY. The aggregation activities in 2-month-old SHRSP showed hardly any difference or a tendency toward lower level than those of WKY of the same age groups, but in the SHRSP of 6 months or more the values were apparently lower than the WKY of the same ages. In contrast, WKY did not show such age-related changes as in SHRSP, and platelet aggregation was always maintained at high level in any age groups. We further noted that the platelet count in SHRSP was decreased with aging. These results suggest that the development of hypertension accounts for much platelet consumption attributed to aging and that the platelet whose aggregation is at normal level is reduced in number. The concomitant degeneration of endothelium may occur in SHRSP due to higher blood pressure.
近畿大学の論文
1987-12-30