<予防および治療>カルシウム拮抗薬(NB-818)の2月齢SHRSPに対する慢性経口投与実験

概要

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The chronic effects of calcium antagonist NB-818 were compared with those of nifedipine on 2-month-old SHRSP. In both 30 mg/kg/day drug administered groups, the blood pressure was always lowered by 20-44 mmHg with retardation of hypertensive arterial changes in ocular fundus, especially in the NB-818 treated group, compared with the non-treated group. Average life spans were as follows 57.3 weeks (control), 54.0 weeks (3mg/kg/day of NB-818), 67.4 weeks (30mg/kg/day of NB-818) and 66.7 weeks (30mg/kg/day of nifedipine). At autopsy, aneurysms in mesenteric arterial arcade and nephrosclerosis were less apparent in both drug treated groups than in the control group. From these findings, we conclude that NB-818 has potent hypotensive effects that equal or surpass nifedipine with a retarding effect on hypertensive arterial changes.
近畿大学の論文
1990-12-30