<血行動態に関する研究>α_1-遮断薬ブナゾシンが意識下SHRSPの血行動態に与える影響

概要

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The acute hemodynamic effects of bunazosin, a specific α_1-antagonist were studied in 6-month-old stroke-prone spontaneously hypertensive rats (SHRSP). The radioactive microsphere technique was used to estimate regional blood flow and cardiac output before and after intravenous injection of bunazosin (0.01 mg/kg). We found a moderate decrease in mean arterial pressure, little change in heart rate, and a large decrease in the total pheripheral resistance index concomitant with a large increase in cardiac index. Regional resistance decreased significantly in the skeletal muscles, but those in the brain, heart, kidney, skin and gastorointestinal tract were not changed. These findings indicate that α_1-receptors on the arteries regulate regional circulation mainly in the skeletal muscle of SHRSP.
近畿大学の論文
1994-12-30