SHRSPの加齢と副腎, 大動脈, 腸間膜動脈のアンジオテンシンII結合活性の変化について(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
In order to examine the postsynaptic role of angiotensin II (AII) for hypertension, we measured the AII binding activities in the adrenal gland, aorta and mesenteric artery prepared from SHRSP and WKY as the control, aged 1.5,3.6 and 12 months after birth by the receptor binding assay using tritium labeled AII. In all the organs used, no major difference in dissociation constant (Kd) values at every age was observed between SHRSP and WKY. Although no major difference in maximal binding activities (Bmax) of the adrenal gland and aorta at every age was also observed between SHRSP and WKY, only Bmax values of the mesenteric artery in 1.5-month-old SHRSP were higher compared with age-matched WKY. These results indicate that the increased density of resistant arterial AII receptors in young SHRSP may play a role in the development of high blood pressure in this model of spontaneous hypertension.
近畿大学の論文
1985-12-30