<原著>子宮および卵膜のカルモデュリンに関する研究 : 特に分娩発来機序との関連性について

概要

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Calmodulin concentration in pregnant rat uteri increased gradually and reached a level about three times that in non-pregnant rat at term. In human beings, uterine calmodulin content at term was about three times that in non-pregnant uteri, but there was not significant difference between the levels in uteri at term with and without labor pain. Estrogen increased the rat uterine calmodulin concentration, but progesterone did not change it. On the other hand, the activity of phospholipase A_2 and C, thought to be the key enzymes in prostaglandins synthesis, in human fetal membranes is stimulated by the addition of calmodulin and inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalsulfonamide, a calmodulin inhibitor. The calmodulin concentration in rat fetal membranes was found to increase as pregnancy advances, but no difference was found in full term preparturient and parturient calmodulin concentration in human fetal membranes. Accordingly, while calmodulin in fetal membrane is believed to play an important role in prostaglandins synthesis, it may not be directlg related to the initiation of parturition. In order to study furthermore, Ca^<2+> concentrations in uteri and fetal membrane during pregnancy were investigated.
近畿大学の論文
1986-03-25