<原著>SHR, SHRSPの高血圧発症とアンギオテンシンI変換酵素(ACE)との関連性についての一考察

概要

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We measured the angiotensin converting enzyme (ACE) activities in the serum and 12,000g supernatant of the 10% homogenate or homogenate of several tissues prepared from spontaneously hypertensive rat (SHR), stroke-prone SHR (SHRSP) and normotensive Wistar Kyoto rat (WKY) by the method of Cushman and Cheung, using hippuryl-L-histidyl-L-leucine. In the serum, the ACE activities of SHR and SHRSP were about half the value of WKY at every age, even at 1.5 months-old. In addition, these activities decreased gradually with age. In the lung, no major difference in the activity was observed between SHR (SHRSP) and WKY, except in 4 month-old rats. In the aorta, SHRSP showed higher ACE activities compared with WKY, but SHR did not. In the lung and aorta, ACE activities of 12 month-old WKY and SHRSP were lower than those of the corresponding 6 month-old rats. In the mesenteric artery, one of the resistant arteries, the ACE activities of SHR were lower than that of 4 month-old WKY, and we obtained a similar result in the endothelial cell fractions after collagenase treatment. In the kidney and liver, these activities in SHR were lower than that of 1.5 month-old WKY. These results suggest that although ACE levels might not have a definite clinical relevance, low ACE activities in the serum of SHR or SHRSP might be a key to prove the causes of hypertension.
近畿大学の論文
1984-12-30