β作用薬(サルブタモール)によるラット大動脈サイクリックAMP合成分解系の解析SHRSPとWKYの比較(II 予防および治療)(A 基礎的研究)

概要

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It has been reported that the effects of CAMP and / or beta-stimulants are reduced in the blood vessels in the animal with high blood pressure. In this experiment, CAMP producing and degrading systems stimulanted by the beta-stimulant, salbutamol, were compared with each other in the aortae of SHRSP and WKY and following conclusions were obtained. 1) In an aging process the CAMP contents in the aorta of SHRSP increased but that of WKY was not changed. 2) CAMP producing activities in the aortae of both SHRSP and WKY were decreased with age, though the decrease was higher in WKY than SHRSP. These activities were higher in the aortae of SHRSP than those in the aortae of WKY at 3,6,and 12 months old. 3) CAMP degrading activities in the aortae of SHRSP were almost equal to those of WKY. 4) Since relaxation responses to beta-stimulants were much lowered in the arteries of SHRSP compared with those of WKY, it is suggested that some unknown steps subsequent to CAMP accumulation by beta-stimulants are involved and may interfere with the relaxation system in arteries of SHRSP.
近畿大学の論文
1982-12-31