<原著>モルモット精嚢におけるIsoproterenolの弛緩作用とCyclic AMPとの関連

概要

論文の詳細を見る
By using the isolated seminal vesicles from guinea pigs, the effects of isoproterenol and dibutyryl cyclic AMP on the responses to ACh and Ca were investigated, especially in relation to cyclic AMP contents. The following results were obtained. 1. Isoproterenol inhibited the contractions produced by ACh and Ca. The limited inhibition was found. 2. Isoproterenol increased the cyclic AMP contents. Also, the limited increase was found. 3. Dibutyryl cyclic AMP inhibited the contractions by ACh and Ca in a dose-dependent manner. The contractions were completely inhibited by the higher concentrations of dibutyryl cyclic AMP. From these results, the following suggestions were obtained ;(1) the relaxation produced by isoproterenol is due to the increased cyclic AMP and (2) there is the limitation in the increase of cyclic AMP produced by the excitation of beta-receptor in the seminal vesicles from guinea pigs.
近畿大学の論文
1983-03-25