<原著>PapaverineおよびAminophyllineの平滑筋弛緩機序, とくにcyclic AMPの関連の立場から

概要

論文の詳細を見る
The spasmolytic actions of papaverine and aminophylline were investigated in relation to cyclic AMP in the isolated seminal vesicles from guinea pigs. Papaverine inhibited the responses to the contractile agents (K, Ba, Ca and ACh) in a dose-dependent manner. The inhibition was larger in the responses to K and Ca than in those to ACh and Ba. The contents of cyclic AMP were increased by papaverine in a dose-dependent manner. Thus, a remarkable correlation was found between the inhibitory effects and the cyclic AMP increasing action. Aminophylline inhibited the responses to the contractile agents tested in the low concentrations, but in the high concentrations potentiated the responses to the contractile agents. The pontentiation was larger in the responses to K and Ca than in those to Ba and ACh. While, the increase of cyclic AMP contents by aminophylline was dose-dependent. Thus, no correlation was found between the inhibitory effects and the increaseing effects of cyclic AMP in aminophylline.
近畿大学の論文
1982-12-25