SHRSPとWKYの摘出大動脈における内皮依存性弛緩反応について

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The relationship between hypertension and endothelium-dependent vasodilation of the isolated aorta strips was investigated in stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY). Acetylcholine (ACh) (10^<-8>-10^<-5>M) and ATP (10^<-7>-2×10^<-5>M) produced a dose-dependent vasodilation of both rats aortas previously contracted by 10^<-7>M norepinephrine (NE) and 3×10^<-7> M prostaglandin (PG) F_<2α>. The vasodilation was completely abolished by removal of the endothelium. The maximal relaxation of ACh or ATP of SHRSP was almost the same with or larger than that of WKY at the ages of 1.5,3 and 6 months. This vasodilation also showed little change with the hypertensive process. Sodium nitroprusside (2×10^<-10>-2×10^<-6>M) relaxed both rats aortas contracted by NE and PG F_<2α>, the relaxation being unaffected by removal of the endothelium. This dilation did not vary significantly with the age and between the two strains of rats. The endothelium ultrastructural changes occurred with the increase in blood pressure in SHRSP, being most dramatic at 6 months old. In SHRSP of 3 or 6 months old, the rising endothelial cells showed an irregular surface with vacuoles and buddings, and the adhesion of leukocytes and platelets. Morphometric measurements also represented a significant hypertrophy of endothelial cells in SHRSP at 6 months old. These results suggest that the endothelium-dependent vasodilation exerts little influence on the aortas of SHRSP, although the morphological alteration is seen in the endothelial cells.
近畿大学の論文
1987-12-30

SHRSPとWKYの摘出大動脈における内皮依存性弛緩反応について

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